Region-Specific Reductions in Morphometric Properties and Synaptic Colocalization of Astrocytes Following Cocaine Self-Administration and Extinction

Frontiers in Cellular Neuroscience
Anze TestenKathryn J Reissner

Abstract

While much is known about the effects of cocaine use on the cellular structure and function of neurons and synapses within the brain's reward circuitry, relatively little is known about the effects of cocaine on astrocytes. Given the significant role that astrocytes play in modulating neuronal and synaptic function, this lack of knowledge regarding the role of astroglial adaptations in the neuropathology of drug abuse represents an important investigative need. We recently showed that astrocytes within the nucleus accumbens (NAc) core exhibit decreased volume, surface area, and synaptic colocalization following cocaine self-administration and extinction, compared to NAc astrocytes from saline-administering animals (Scofield et al., 2016b). However, it is unknown whether these cocaine-dependent changes in astrocytes are ubiquitous throughout the brain's reward circuitry, or represent specific adaptations within the NAc. It is also not known whether the extinction period is necessary for the retracted phenotype, or whether self-administration alone is sufficient to drive these changes. In the current study, we have extended our assessment of the effects of cocaine self-administration on morphometric properties and synaptic coloca...Continue Reading

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Citations

Sep 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kathryn J Reissner, Mikhail V Pletnikov
Feb 19, 2020·Current Protocols in Neuroscience·Anze TestenKathryn J Reissner
Aug 18, 2020·Human Molecular Genetics·Alexey V ShevelkinMikhail V Pletnikov
Feb 23, 2021·Journal of Neuroinflammation·Cassandra D GipsonErin E Maher
Apr 11, 2021·Molecular Psychiatry·Junshi WangYan Dong
Aug 31, 2020·Current Opinion in Pharmacology·Anna Kruyer, Peter W Kalivas

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