PMID: 7541101Jan 1, 1995Paper

Regional 5-hydroxyindoleacetic acid production in humans

Life Sciences
G LambertM Esler

Abstract

Veno-arterial plasma concentration differences and regional organ plasma flows were used to quantify the relative amounts of 5-hydroxyindoleacetic acid (5-HIAA) contributed by various sites into the peripheral circulation. Positive venoarterial concentration gradients were found in the hepatosplanchnic, forearm, cardiac and jugular vessels in the healthy subjects. The renal circulation was determined to be the principal site of 5-HIAA clearance, extracting 18 +/- 2 nmol/min. The gut was the greatest contributor to the total 5-HIAA plasma pool with the relative contributions of the various organs being as follows: hepatosplanchnic organs 58%, skeletal muscle 26%, brain 6% and the heart 3%. The source of 5-HIAA stemming from these regional beds remains unknown, it may derive from serotonin taken up by and deaminated in ubiquitous endothelial cells, enterochromaffin cells of the gut, peripheral serotonergic nerves, serotonin turnover in platelets or perhaps the metabolism of serotonin taken up by sympathetic nerves. To test the latter hypothesis we examined 23 patients with chronic congestive heart failure and 9 patients with pure autonomic failure to investigate the possible effects of sympathetic nervous system overactivity and ...Continue Reading

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Citations

Apr 3, 2007·Journal of Neural Transmission·A W CoppusC M van Duijn
Nov 25, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Noriyuki TokunagaHidezo Mori
Jun 15, 2013·Sleep Disorders·Nicholas D TaylorRoss Levin
Jul 9, 2004·Annals of the New York Academy of Sciences·Murray EslerJeff Richards
Jun 3, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D KeszthelyiA A M Masclee
Jul 1, 1997·Clinical and Experimental Hypertension : CHE·M EslerG Jennings
Aug 21, 2013·Physiology & Behavior·Luca MelottiSuzanne Held
Jul 16, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Borwin BandelowPeter Riederer
Jan 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Nina EikelisMurray Esler
Sep 7, 2006·International Journal of Geriatric Psychiatry·Tischa J M van der CammenDurk Fekkes
Oct 29, 2005·The Journal of Physiology·Gavin LambertPetre Nitescu
Jun 29, 2021·Experimental Gerontology·Alessandra GalloRomain Verpillot

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