Abstract
This study sought to test the hypothesis that older obese patients with heart failure with preserved ejection fraction (HFpEF) have significantly greater abdominal, cardiac, and intermuscular fat than healthy, age-matched controls, out of proportion to total body fat, and that these abnormalities are associated with objective measurements of physical function. Recent studies indicate that excess total body adipose tissue contributes to exercise intolerance in patients with HFpEF. However, the impact of the pattern of regional (abdominal, cardiac, intermuscular) adipose deposition on exercise intolerance in patients with HFpEF is unknown. We measured total body adiposity (using dual-energy x-ray absorptiometry) and regional adiposity (using cardiac magnetic resonance), peak oxygen uptake (Vo2), 6-min walk distance (6MWD), short physical performance battery (SPPB), and leg press power in 100 older obese patients with HFpEF and 61 healthy controls (HCs) and adjusted for age, sex, race, and body surface area. Peak Vo2 (15.7 ± 0.4 ml/kg/min vs. 23.0 ± 0.6 ml/kg/min, respectively; p < 0.001), 6MWD (427 ± 7 m vs. 538 ± 10 m, respectively; p < 0.001), SPPB (10.3 ± 0.2 vs. 10.9 ± 0.2, respectively; p < 0.05), and leg power (117 ± 5 W vs...Continue Reading
Citations
May 14, 2019·Diabetes, Obesity & Metabolism·Michael E Nassif, Mikhail Kosiborod
Nov 7, 2019·European Journal of Heart Failure·Cho-Kai WuLian-Yu Lin
Mar 10, 2020·European Journal of Heart Failure·Yogesh N V ReddyBarry A Borlaug
May 22, 2020·Circulation Research·Marie-Eve PichéJean-Pierre Després
May 23, 2020·European Journal of Heart Failure·Milton PackerBarry A Borlaug
Jun 11, 2020·Diabetes/metabolism Research and Reviews·Jee Hee YooJae Hyeon Kim
Jun 7, 2019·Journal of Clinical Medicine·Marijana TadicMaurizio Galderisi
Mar 29, 2020·ESC Heart Failure·Marcelo Rodrigues Dos SantosMaria-Janieire de Nazaré Nunes Alves
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
Apr 7, 2019·Current Hypertension Reports·Thierry H Le JemtelSuzanne Oparil
May 21, 2019·Journal of Cellular Physiology·Daniele FerraraFederico Carbone
Jan 31, 2020·ESC Heart Failure·Daniela TomasoniMarco Metra
Jun 14, 2020·The International Journal of Cardiovascular Imaging·Selcuk KucukseymenReza Nezafat
Jul 2, 2019·Hypertension·Bharathi UpadhyaUNKNOWN SPRINT Research Group *
Jan 6, 2019·Heart Failure Reviews·Marijana Tadic, Cesare Cuspidi
Aug 21, 2019·Frontiers in Cardiovascular Medicine·Albin OhMaria Valero-Muñoz
Sep 5, 2018·Current Heart Failure Reports·Wesley J TuckerDaniel E Forman
Jul 4, 2020·European Journal of Heart Failure·Vishal N RaoG Michael Felker
Nov 10, 2020·Circulation·Kershaw V PatelUNKNOWN Look AHEAD Research Group
Nov 28, 2020·Journal of Cachexia, Sarcopenia and Muscle·Maxime NachitIsabelle Anne Leclercq
Oct 25, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Mi-Hyang JungKyu-Hyung Ryu
Jan 5, 2021·Current Opinion in Cardiology·Eng Leng SawFlora Sam
Feb 10, 2021·JAMA : the Journal of the American Medical Association·Ambarish Pandey, Dalane W Kitzman
Oct 30, 2020·Frontiers in Endocrinology·Danielle L KirkmanSalvatore Carbone
Mar 17, 2021·European Journal of Heart Failure·Jasper TrompCarolyn S P Lam
May 4, 2021·ESC Heart Failure·Wendy YingAllison G Hays
May 4, 2021·Journal of Cachexia, Sarcopenia and Muscle·Masaaki KonishiKazuo Kimura
May 15, 2021·Heart·Sarah L AytonAlastair J Moss
May 30, 2021·BMC Cardiovascular Disorders·Jianqiao ChenHongbin Liu
May 31, 2021·Heart Failure Clinics·Efstratios KoutroumpakisAnita Deswal
May 16, 2021·Journal of Cardiac Failure·Michael F CosianoStephen J Greene
Jul 3, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Andrea Del CampoHugo E Verdejo
Jul 15, 2021·PloS One·Yousuke SugitaShinya Kuno
Jul 24, 2021·European Journal of Heart Failure·Ambarish Pandey, Javed Butler
Aug 25, 2021·European Journal of Heart Failure·Nicola R PuglieseStefano Masi
Oct 17, 2021·European Journal of Heart Failure·Jasper TrompCarolyn S Lam
Jun 23, 2020·Obesity Facts·Feng GaoPeijian Wang
Nov 19, 2021·Journal of Applied Physiology·Rachel C KelleyLeonardo F Ferreira