Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Judith S CurrierFat Redistribution and Metabolic Changes in HIV Infection Study Investigators

Abstract

HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described. Multivariable linear regression analyzed the association between magnetic resonance imaging-measured regional adipose tissue and fasting lipids in 284 HIV-infected and 129 control women. Among African Americans, HIV-infected women had higher triglyceride (116 vs. 83 mg/dL; P < 0.001), similar high-density lipoprotein (HDL; 52 vs. 50 mg/dL; P = 0.60), and lower low-density lipoprotein (LDL; 99 vs. 118 mg/dL; P = 0.008) levels than controls. Among whites, HIV-infected women had higher triglyceride (141 vs. 78 mg/dL; P < 0.001), lower HDL (46 vs. 57 mg/dL; P < 0.001), and slightly lower LDL (100 vs. 107 mg/dL; P = 0.059) levels than controls. After adjustment for demographic and lifestyle factors, the highest tertile of visceral adipose tissue (VAT) was associated with higher triglyceride (+85%, 95% confidence interval [CI]: 55 to 121) and lower HDL (-9%, 95% CI: -18 to 0) levels in HIV-infected women; the highest tertile of leg subcutaneous adipose tissue (SAT) was associated with lower triglyceride levels in HIV-infected women (-28%, 95% CI: -41 to -11) and controls (-39...Continue Reading

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Citations

Jul 20, 2011·AIDS Care·Jordan E LakeJudith S Currier
May 27, 2010·AIDS·Carl GrunfeldUNKNOWN Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM)
Dec 2, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Julie A WomackPhyllis C Tien
Feb 18, 2009·HIV Medicine·Pl WilliamsUNKNOWN AIDS Clinical Trials Group 362 Study Team
Aug 8, 2008·The Journal of Clinical Endocrinology and Metabolism·Todd T Brown
Dec 16, 2011·HIV Therapy·Jordan E Lake, Judith S Currier
Jan 15, 2014·International Journal of Epidemiology·David G DillonUNKNOWN African Partnership for Chronic Disease Research (APCDR)
Sep 20, 2011·The Journal of the Association of Nurses in AIDS Care : JANAC·Sara E Dolan Looby
Jun 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael P Dubé, Joseph J Cadden
Jun 12, 2010·Obesity·Rebecca ScherzerUNKNOWN Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM)
Nov 23, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Sadeep ShresthaDonna K Arnett
Mar 20, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cynthia L GibertUNKNOWN International Network for Strategic Initiatives in Global HIV Trials
Jun 11, 2008·The American Journal of Clinical Nutrition·Rebecca ScherzerUNKNOWN Study of Fat Redistribution Metabolic Change in HIV Infection (FRAM)

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