Regional adipose tissue metabolism in postmenopausal women after treatment with exogenous sex steroids

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
U B LindbergM Rebuffé-Scrive

Abstract

In order to evaluate the effect of exogenous sex steroids on adipose tissue metabolism, two groups of postmenopausal women were studied. In one of the groups, the effect of 50 micrograms ethinyl estradiol (EE) was investigated given orally alone and in combination with 10 mg norethisterone acetate (NET). This combination is reminiscent of an old high dose oral contraceptive. In the other group, the effect of 3 mg 17 beta-estradiol was evaluated when administered percutaneously alone and in combination with 300 mg micronized progesterone given orally. These substances and doses were chosen to provide a "physiological" hormonal influence. In the femoral region 50 micrograms EE induced an increase in LPL activity. This elevated LPL value was reversed with the addition of 10 mg NET. Moreover, during treatment with 50 micrograms EE, a decrease in norepinephrine stimulated lipolysis was seen in the abdominal region. The percutaneous administration of 17 beta-estradiol with or without micronized progesterone, however, was inert as regards subcutaneous adipose tissue metabolism. Our findings indicate, therefore, that EE in doses used in oral contraception might promote lipid accumulation in the femoral adipose tissue depot.

Citations

May 13, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A BongainJ Y Gillet
Mar 16, 2006·Journal of Women's Health·Ellen M Evans, Susan B Racette
Feb 4, 1999·Journal of Women's Health·J C Lovejoy
Mar 25, 1999·Clinical Therapeutics·B de Lignières
Mar 12, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J C LovejoyS R Smith
Jun 13, 2012·Breast Cancer Research and Treatment·Marina PollánUNKNOWN DDM-Spain
Mar 3, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S C HoA Sham
Jan 28, 2012·Maturitas·Angelica Lindén Hirschberg
Nov 22, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J C LovejoyUNKNOWN Stock Conference 2008 Working Group
Dec 18, 2012·Periodontology 2000·Beatrice J Edwards, Jin Li
Feb 18, 1998·American Journal of Obstetrics and Gynecology·T M PriceM Kilgore
Jun 9, 1998·Obesity Research·A Tchernof, E T Poehlman
Jul 22, 2008·Metabolism: Clinical and Experimental·Marie-Eve PichéSimone Lemieux
Oct 2, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J S Mayes, G H Watson
Dec 26, 2006·Obesity·Rachael E Van PeltWendy M Kohrt
Jul 13, 2006·American Journal of Physiology. Endocrinology and Metabolism·Faidon MagkosBettina Mittendorfer
Aug 12, 2018·Journal of Lipid Research·Aaron P FrankDeborah J Clegg
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Cynthia M FerraraDora M Berman
Mar 28, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kathleen M GavinRobert C Hickner
Aug 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeung-Ki Yoo, Qi Fu
Aug 23, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Eric T Poehlman
Dec 12, 2020·Medical Hypotheses·L KeithM Carmody
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G N Wade, J E Schneider

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.