Regional and cellular expression of the mannose receptor in the post-natal developing mouse brain

Cell and Tissue Research
E M Burudi, A Régnier-Vigouroux

Abstract

The mannose receptor, a glycoprotein expressed in a soluble and membrane form by macrophages, plays an important role in homeostasis and immunity. Using biochemical and immunohistochemical analyses, we demonstrate that this receptor, both in its soluble and membrane forms, is expressed in vivo in the post-natal murine brain and that its expression is developmentally regulated. Its expression is at its highest in the first week of life and dramatically decreases thereafter, being maintained at a low level throughout adulthood. The receptor is present in most brain regions at an early post-natal age, the site of the most intense expression being the meninges followed by the cerebral cortex, brain stem and the cerebellum. With age, expression of the mannose receptor is maintained in regions such as the cerebral cortex and the brain stem, whereas it disappears from others such as the hippocampus or the striatum. In healthy brain, no expression can be detected in oligodendrocytes, ependymal cells, endothelial cells or parenchymal microglia. The mannose receptor is expressed by perivascular macrophages/microglia and meningeal macrophages, where it might be important for the brain immune defence, and by two populations of endogenous b...Continue Reading

Citations

Oct 23, 2002·Journal of Neurochemistry·M TomásJ Renau-Piqueras
Jan 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cheryl A Hawkes, Joanne McLaurin
Aug 19, 2004·Journal of Neuroinflammation·Tammy Kielian
Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kathryn M LenzMargaret M McCarthy
Jun 4, 2014·Journal of Neuroinflammation·Jonathan D CherryM Kerry O'Banion
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·J Roberto TrujilloJoseph D Brain
Jul 4, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cathy J JensenJacques De Keyser
Jul 26, 2006·The Journal of Cell Biology·Katie M Jansen, Grace K Pavlath
Aug 21, 2009·Journal of the Peripheral Nervous System : JPNS·Wagner Baetas-da-CruzLeny A Cavalcante
Apr 18, 2007·Journal of Neurochemistry·A VaslinP G H Clarke
Dec 7, 2007·Journal of Neuroscience Research·Jeppe FalsigMarcel Leist
Oct 10, 2013·Journal of Neuroscience Research·Litia A CarvalhoLeny A Cavalcante
Mar 31, 2012·Brain Research·Arthur Giraldi-GuimarãesWagner Baetas-da-Cruz
Apr 19, 2013·Biomedical Research·Yutaka Masuda, Toshihiro Sugiyama
Jan 31, 2006·The Biochemical Journal·Catherine E NapperMaureen E Taylor
Jan 11, 2020·Frontiers in Immunology·Arden G Vanderwall, Erin D Milligan

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