PMID: 11331670May 2, 2001Paper

Regional and cellular localization of osteonectin/SPARC expression in connective tissue and cytotrophoblastic layers of human fetal membranes at term

Molecular Human Reproduction
P C McParlandD J Taylor

Abstract

Fetal membranes overlying the cervix in patients prior to and during labour, and within the rupture tear after spontaneous delivery at term, exhibit altered morphology. In this study we report that in comparison to mid-zone fetal membranes biopsies, these regions are characterized by increased expression of the matricellular protein osteonectin or SPARC (Secreted Protein Acidic and Rich in Cysteine). In the reticular layer, the percentage of vimentin positive mesenchymal cells immunoreactive for osteonectin increased in these regions from 3-4% to 25-33% and represented a fraction of the alpha-smooth muscle actin positive myofibroblasts elevated in the same regions. In the fibroblastic layer, the percentage of osteonectin positive cells increased from 1-5% to 8-13%; however, these did not exhibit the same relationship to the alpha-smooth muscle actin positive myofibroblasts in this layer. In the cytotrophoblastic layer the percentage of cytotrophoblastic cells immunoreactive for osteonectin increased from 1% to 6-12%. Elevation of in-situ detectable mRNA was also observed in the same cellular populations in this region. The incidence of cells positive for osteonectin mRNA or protein in the reticular layer correlated with morphol...Continue Reading

References

Feb 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S MundlosB Zabel
May 1, 1992·American Journal of Obstetrics and Gynecology·R S GibbsR L Sweet
Jun 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H SageM L Iruela-Arispe
Dec 1, 1986·Clinical Obstetrics and Gynecology·L S Alger, M J Pupkin
Jan 1, 1981·Cell and Tissue Research·M N Bou-ResliM E Ibrahim
Aug 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P L PorterA M Gown
Apr 1, 1995·Current Opinion in Obstetrics & Gynecology·T Kelly
Apr 15, 1994·Biochemical and Biophysical Research Communications·K KamihagiI Kato
Oct 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J ReedE H Sage
Oct 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M L Iruela-ArispeE H Sage
Oct 1, 1996·Seminars in Perinatology·J I French, J A McGregor
Dec 1, 1996·Kidney International·R H PichlerW G Couser
May 1, 1997·Kidney International·K Motamed, E H Sage
Nov 25, 1997·Journal of Cellular Physiology·U T ShankavaramL M Wahl
Mar 5, 1998·The New England Journal of Medicine·S Parry, J F Strauss
Mar 21, 1998·The American Journal of Surgical Pathology·W SchürchG Gabbiani
Dec 1, 1998·The Journal of Physiology·D W Powell
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
Nov 24, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Q Yan, E H Sage
Jan 21, 2000·The International Journal of Biochemistry & Cell Biology·K Motamed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.