PMID: 6109001Oct 1, 1980Paper

Regional and subcellular distribution of ATP-citrate lyase and other enzymes of acetyl-CoA metabolism in rat brain

Journal of Neurochemistry
A Szutowicz, W Lysiak

Abstract

The activities of ATP-citrate lyase in frog, guinea pig, mouse, rat, and human brain vary from 18 to 30 mu mol/h/g of tissue, being several times higher than choline acetyltransferase activity. Activities of pyruvate dehydrogenase and acetyl coenzyme A synthetase in rat brain are 206 and 18.4 mu mol/h/g of tissue, respectively. Over 70% of the activities of both choline acetyltransferase and ATP-citrate lyase in secondary fractions are found in synaptosomes. Their preferential localization in synaptosomes and synaptoplasm is supported by RSA values above 2. Acetyl CoA synthetase activity is located mainly in whole brain mitochondria (RSA, 2.33) and its activity in synaptoplasm is low (RSA, 0.25). The activities of pyruvate dehydrogenase, citrate synthase, and carnitine acetyltransferase are present mainly in fractions C and Bp. No pyruvate dehydrogenase activity is found in synaptoplasm. Striatum, cerebral cortex, and cerebellum contain similar activities of pyruvate dehydrogenase, citrate synthase, carnitine acetyltransferase, fatty acid synthetase, and acetyl-CoA hydrolase. Activities of acetyl CoA synthetase, choline acetyltransferase and ATP-citrate lyase in cerebellum are about 10 and 4 times lower, respectively, than in o...Continue Reading

References

Dec 1, 1975·The Biochemical Journal·G L ReijnierseC J Van der Ber
Jul 1, 1975·Journal of Neurochemistry·A SzutowiczS Angielski
Aug 1, 1978·Journal of Neurochemistry·G H Sterling, J J O'Neill
Aug 1, 1977·Journal of Neurochemistry·A SzutowiczS Angielski
May 1, 1975·Journal of Neurochemistry·R J Wenthold, H R Mahler
Aug 1, 1974·The Biochemical Journal·S E KnowlesF J Ballard
Apr 1, 1973·Journal of Neurochemistry·P LefresneJ Glowinski
Dec 1, 1973·Journal of Neurochemistry·H I Yamamura, S H Snyder
Jun 1, 1974·Journal of Neurochemistry·M J Kuhar, J R Simon
Jan 1, 1965·Progress in Biophysics and Molecular Biology·V P Whittaker
Oct 28, 1970·Brain Research·J C SmithA F D'Adamo
Mar 1, 1971·Hoppe-Seyler's Zeitschrift für physiologische Chemie·E SiessO Wieland
Oct 1, 1968·The Journal of Clinical Investigation·D W McCandlessM Cook
Mar 1, 1966·The Biochemical Journal·D Morris

❮ Previous
Next ❯

Citations

Jul 1, 1982·Neurochemical Research·A SzutowiczW Lysiak
Jan 1, 1980·The International Journal of Biochemistry·S SzutowiczW Lysiak
Jan 1, 1981·The International Journal of Biochemistry·A SzutowiczW Lysiak
Jan 1, 1984·Progress in Biophysics and Molecular Biology·S Tucek
May 7, 2009·Journal of Neurochemistry·Dinesh K DeelchandPierre-Gilles Henry
Oct 3, 2007·The European Journal of Neuroscience·Sachin PatilChristina Chan
Jun 10, 2010·The Journal of Comparative Neurology·Prasanth S AriyannurAryan M A Namboodiri
Jul 1, 1982·Journal of Neurochemistry·Y N Kwok, B Collier
Jan 1, 1984·Journal of Neurochemistry·K F SheuJ P Blass
Jun 1, 1985·Journal of Neurochemistry·G V Johnson, C R Hartzell
Feb 26, 2015·Annals of Neurology·Fuzheng GuoDavid Pleasure
May 27, 2006·Physiology & Behavior·Eva M R Kovacs, Margriet S Westerterp-Plantenga
Jul 28, 2018·Frontiers in Cellular Neuroscience·Anna RonowskaAgnieszka Jankowska-Kulawy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.