Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious rats

British Journal of Anaesthesia
T BennettS M Gardiner

Abstract

Reduced pressor responsiveness to norepinephrine (NE) in sepsis is well documented but the associated regional haemodynamic changes are less well characterized, and there are varying reports of changes in haemodynamic responses to arginine vasopressin (AVP). We compared changes in regional haemodynamic responsiveness to AVP and NE during a 24 h continuous infusion of lipopolysaccharide (LPS) in conscious rats. Conscious, male Sprague-Dawley rats were infused with saline (0.4 ml h(-1)) or LPS (150 micro g kg(-1) h(-1)). Renal, mesenteric, and hindquarter haemodynamic responses to 3 min infusions of AVP (0.25, 0.625, and 1.25 ng kg(-1) min(-1)) or NE (75, 250, and 750 ng kg(-1) min(-1)) were assessed 2, 6, and 24 h after the onset of LPS or saline. Two and six hours after the onset of LPS, all haemodynamic effects of NE were markedly reduced, but by 24 h, there was some recovery in the vasoconstrictor actions of NE although the pressor and bradycardic effects were still depressed. Two hours after the onset of LPS, the cardiovascular effects of AVP were depressed but there was some recovery in vascular responsiveness at 6 h. By 24 h, only the mesenteric vasoconstrictor effect of AVP was consistently reduced. During low dose LPS in...Continue Reading

References

Apr 1, 1986·Clinical Science·T Bennett, S M Gardiner
Dec 1, 1986·Brain Research·S M Gardiner, T Bennett
Mar 1, 1980·Pharmacology, Biochemistry, and Behavior·R BlairJ R Weeks
Aug 1, 1997·Critical Care Medicine·D W LandryJ A Oliver
Sep 1, 2001·The New England Journal of Medicine·D W Landry, J A Oliver
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Johannes PleinerMichael Wolzt
Apr 17, 2002·Lancet·Alastair O'BrienMervyn Singer
Jan 22, 2003·Drugs·Martin W DunserWalter R Hasibeder
Feb 11, 2003·Critical Care Medicine·Michael BucherArmin Kurtz
May 6, 2003·The Journal of Pharmacology and Experimental Therapeutics·Matthew R FarmerVera Ralevic
Jun 7, 2003·American Journal of Respiratory and Critical Care Medicine·Qinghua SunJean-Louis Vincent
Jun 10, 2003·Critical Care Medicine·Tarek SharsharDjillali Annane
Nov 8, 2003·Critical Care Medicine·Stefan KlinzingAndreas Meier-Hellmann
Nov 25, 2003·Anesthesia and Analgesia·Tero J MartikainenEsko Ruokonen
Dec 9, 2003·Cardiovascular Research·Ali El-ArmoucheThomas Eschenhagen

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Citations

Nov 30, 2006·Critical Care Medicine·Lucinda K BarrettLucie H Clapp
Feb 27, 2009·Critical Care Medicine·Yan LiPeter Q Eichacker
Aug 8, 2008·Best Practice & Research. Clinical Anaesthesiology·Pierre AsfarPeter Radermacher
Apr 16, 2013·British Journal of Pharmacology·L V Fretwell, J Woolard
Jul 29, 2015·Intensive Care Medicine Experimental·Benjamin Aj ReddiDavid P Wilson
Nov 16, 2012·Research in Veterinary Science·Yulin YanYongke Sun
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Jan 4, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Abdalla M WednMahmoud M El-Mas
Feb 25, 2021·Shock·Mariane C G Leite-AvalcaChristian Lehmann

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