Regional and temporal differences in real-time dopamine efflux in the nucleus accumbens during free-choice novelty

Brain Research
George V RebecM T Bardo

Abstract

To assess dopamine efflux during novelty-seeking behavior in rats, fast-scan cyclic voltammetry in the nucleus accumbens was combined with free-choice entry into a novel environment. Cyclic voltammograms, confirmed by in vitro testing, revealed that entry into novel, but not familiar, surroundings increased dopamine efflux in a regionally and temporally distinct pattern. Whereas dopamine failed to change in the core region of the accumbens and overlying neostriatum, an abrupt increase occurred in accumbal shell, a limbic-related area implicated in goal-directed behavior. Although the dopamine response was confined to the brief period of entry into novelty (approximately 8 s duration), a less rapid and more persistent dopamine change (> 20 s duration) occurred in the shell-core transition zone, the so-called shore. These results suggest that novelty mimics other positively reinforcing stimuli in enhancing dopamine transmission in the nucleus accumbens, but the regional and temporal heterogeneity of this effect may represent different aspects of accumbal dopamine function.

References

Oct 1, 1975·Journal of Experimental Psychology. Animal Behavior Processes·M Mishkin, J Delacour
Dec 15, 1990·The Journal of Comparative Neurology·D S Zahm, L Heimer
Jan 1, 1990·Progress in Neurobiology·R N Adams
Jun 1, 1990·Pharmacology, Biochemistry, and Behavior·R C PierceM T Bardo
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Jul 1, 1988·Analytical Chemistry·J E BaurR M Wightman
Oct 1, 1988·Neurochemical Research·R AllinJ J Taljaard
Aug 27, 1986·Brain Research·W G Kuhr, R M Wightman
Jul 1, 1995·Brain Research. Cognitive Brain Research·S J SaraA Hervé
Jul 1, 1993·Journal of Neuroscience Methods·K T KawagoeR M Wightman
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·F E PontieriG Di Chiara
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·E A Kiyatkin
May 1, 1996·Behavioural Brain Research·M T BardoN G Harrington
Aug 1, 1955·Journal of Comparative and Physiological Psychology·D E BERLYNE

❮ Previous
Next ❯

Citations

Feb 14, 2002·Synapse·Paul E M PhillipsJonathan A Stamford
Nov 23, 2006·Psychopharmacology·Paul E M PhillipsThomas C Jhou
May 12, 2004·Behavioural Brain Research·David A Wood, George V Rebec
Oct 2, 2003·European Journal of Pharmacology·Claire S Shilliam, Christian A Heidbreder
Nov 10, 2012·Journal of Electroanalytical Chemistry·Tina T-C Tseng, Harold G Monbouquette
Aug 2, 2002·Pharmacology, Biochemistry, and Behavior·Cornelius R Pawlak, Rainer K W Schwarting
May 7, 2003·Neuroscience and Biobehavioral Reviews·Giovanni LaviolaWalter Adriani
Jun 28, 2002·Trends in Neurosciences·Raúl de la Fuente-Fernández, A Jon Stoessl
Nov 13, 2001·Behavioural Brain Research·J BesheerR A Bevins
Nov 26, 2002·Behavioural Brain Research·Paul A Garris, George V Rebec
Jun 16, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·C A HeidbrederJ Feldon
Jun 26, 2008·Chemical Reviews·Donita L RobinsonR Mark Wightman
Apr 21, 2005·Behavioral Neuroscience·Norman Pecoraro, Mary F Dallman
Apr 16, 2008·Behavioral Neuroscience·Ceyhun Sunsay, George V Rebec
Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christopher M Olsen, Danny G Winder
Nov 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Garret D StuberR Mark Wightman
Jun 16, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neil M RichtandRobert K McNamara
May 20, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew J SmithShitij Kapur
Aug 10, 2001·Neuroreport·D L RobinsonR M Wightman
Dec 12, 2012·PloS One·Caroline HanssonKarolina P Skibicka
Sep 5, 2012·Reviews in the Neurosciences·Matthew C HearingKevin Wickman
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefanie GeislerDaniel S Zahm
Nov 9, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aneesha BadrinarayanBrandon J Aragona
Jan 26, 2011·Cognitive, Affective & Behavioral Neuroscience·Colin M Stopper, Stan B Floresco
Aug 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amir Segev, Irit Akirav

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.