Regional assignment of conserved reference loci anchors unassigned linkage and syntenic groups to ovine chromosomes

Genomics
H A AnsariT E Broad

Abstract

Seven loci that have been previously mapped to human and mouse chromosomes have now been regionally assigned to six sheep chromosomes. Nerve growth factor beta (NGFB), antigen CD3 zeta polypeptide (CD3Z), inhibin beta A (INHBA), estrogen receptor (ESR), rhodopsin (RHO), insulin-like growth factor 2 (IGF2), and myelin basic protein (MBP) were mapped by in situ hybridization to sheep chromosomes 1p24-p21, 1p14-p11, 4q26-q31, 8q25-q27, 19q23-qter, 21q21-qter, and 23q11-q12.3, respectively. ESR, RHO, IGF2, and MBP are the first markers to be assigned to their respective sheep chromosomes. These new data allow the previously unassigned sheep linkage groups H, J, K, and S to be provisionally assigned to chromosomes 21, 19, 4, and 8, respectively. The unassigned sheep syntenic groups U8 and U13 are provisionally assigned to sheep chromosomes 8 and 21, respectively. The new assignments support the emerging picture that there is extensive conservation of human chromosomal segments in the sheep and cattle genomes. The position of another evolutionary breakpoint on human chromosome 1q is suggested.

Citations

Jul 23, 2003·Animal Genetics·J J Goodall, S M Schmutz
Dec 5, 2003·Mechanisms of Development·Lorraine E YoungRobert Feil
Apr 29, 2006·Genomics·Claudia GebertHeiner Niemann
Aug 1, 1995·Animal Genetics·G W MontgomeryD F Hill
Aug 1, 1995·Animal Genetics·A Eggen, R Fries
Jan 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H A AnsariT E Broad
Aug 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T E BroadC Jones
Jun 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·F PitelJ Gellin
May 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M R AmaranteT E Broad
Aug 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·T RaudseppB P Chowdhary

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