Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue.

Molecular Neurodegeneration
Laetitia LemoineAnn-Charlotte Granholm

Abstract

Tau pathology is a major age-related event in Down syndrome with Alzheimer's disease (DS-AD). Although recently, several different Tau PET tracers have been developed as biomarkers for AD, these tracers showed different binding properties in Alzheimer disease and other non-AD tauopathies. They have not been yet investigated in tissue obtained postmortem for DS-AD cases. Here, we evaluated the binding characteristics of two Tau PET tracers (3H-MK6240 and 3H-THK5117) and one amyloid (3H-PIB) ligand in the medial frontal gyrus (MFG) and hippocampus (HIPP) in tissue from adults with DS-AD and DS cases with mild cognitive impairment (MCI) compared to sporadic AD. Tau and amyloid autoradiography were performed on paraffin-embedded sections. To confirm respective ligand targets, adjacent sections were immunoreacted for phospho-Tau (AT8) and stained for amyloid staining using Amylo-Glo. The two Tau tracers showed a significant correlation with each other and with AT8, suggesting that both tracers were binding to Tau deposits. 3H-MK6240 Tau binding correlated with AT8 immunostaining but to a lesser degree than the 3H-THK5117 tracer, suggesting differences in binding sites between the two Tau tracers. 3H-THK5117, 3H-MK6240 and 3H-PIB dis...Continue Reading

References

Oct 10, 2003·Journal of Neuropathology and Experimental Neurology·E HeadC W Cotman
Aug 19, 2007·Brain : a Journal of Neurology·A LockhartT G Beach
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michelle T Fodero-TavolettiVictor L Villemagne
Jun 11, 2009·International Journal of Geriatric Psychiatry·V P PrasherN Schupf
Apr 7, 2010·Journal of Intellectual Disability Research : JIDR·D Adams, C Oliver
Aug 30, 2012·Nature Methods·Caroline A SchneiderKevin W Eliceiri
Mar 1, 2013·Neurology·Clifford R JackRonald C Petersen
Dec 17, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dean HartleyThomas Wisniewski
Jul 3, 2015·Acta Neuropathologica Communications·Laetitia LemoineAgneta Nordberg
Dec 15, 2015·Current Alzheimer Research·Elizabeth HeadCynthia A Lemere
Feb 19, 2016·Dementia and Geriatric Cognitive Disorders·Luciana Mascarenhas FonsecaDaniel Fuentes
Oct 19, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Eric D HamlettAnn-Charlotte Granholm
Dec 13, 2016·Journal of Neurochemistry·Ghiam Yamin, David B Teplow
Apr 8, 2017·Neurobiology of Aging·Harry LeVineElizabeth Head
Apr 30, 2017·Neuropathology and Applied Neurobiology·I MilenkovicG G Kovacs
Jul 18, 2017·Neurobiology of Aging·Sigan L HartleyBradley T Christian
Sep 28, 2017·Journal of Alzheimer's Disease : JAD·Michael S RafiiUNKNOWN Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative
Nov 22, 2017·NeuroImage. Clinical·Natalie NealeShahid Zaman
May 20, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tobey J BetthauserBradley T Christian
May 22, 2018·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Laetitia LemoineAgneta Nordberg
Jun 22, 2018·Annals of Clinical and Translational Neurology·Nicholas C FirthAndré Strydom
Sep 13, 2018·Alzheimer's Research & Therapy·Michael Malek-AhmadiElliott J Mufson
Jan 13, 2019·Molecular Psychiatry·Antoine LeuzyAgneta Nordberg

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Citations

Jun 8, 2021·Pharmacogenomics and Personalized Medicine·Dubravka Svob StracNela Pivac
Aug 8, 2021·Journal of Clinical Medicine·David G MorenoSylvia E Perez
Aug 27, 2021·Frontiers in Aging Neuroscience·Sonia Do CarmoA Claudio Cuello
Nov 11, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mariko SawaWilliam C Mobley

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