Regional blood flow during reactive hyperemia in canine myocardium as determined by local washout of xenon-133

Acta Physiologica Scandinavica
S Haunsø, O Amtorp

Abstract

The mechanisms regulating vascular tone in the myocardium were studied in open-chest anesthetized dogs by occlusions of the left anterior descending coronary artery (LAD) for 3 to 600 s. Cumulative excess blood flow (flow in excess of control flow), and repayment of flow debt (cumulative excess blood flow divided by blood flow deficity) were calculated using local injections of Xenon-133 for blood flow measurements. Release of vascular occlusion following 3 s of ischemia was not associated with any measurable hyperemia. Cumulative excess blood flow increased with increasing duration of ischemia from 5 to 600 s, but the increment in excess flow per unit extention of the occlusion time showed a considerable decline. Blood flow in excess exceeded blood flow diet incurred during the occlusion of 10 s duration of 161%; with prolongation of ischemia to 600 s repayment of flow debt declined markedly to about 10%. Oxygen lack in the tissue elicited by perfusion of LAD-for 10 s with constant perfusion rate-with deoxygenated blood produced a fall in peripheral coronary resistance of about 40% which closely corresponds to the fall in resistance observed after a period of LAD occlusion of similar duration. The results lead to the conclusio...Continue Reading

References

Feb 1, 1975·Journal of Molecular and Cellular Cardiology·R A ThomasR M Berne
Jun 1, 1975·The Journal of Clinical Investigation·R W AlexanderT Cooper
Jan 1, 1977·Cardiovascular Research·R W Giles, E L Wilcken
Oct 1, 1976·Acta Physiologica Scandinavica·L Henriksen, P Sejrsen
Sep 1, 1975·Progress in Cardiovascular Diseases·R Rubio, R M Berne
Sep 1, 1975·Circulation Research·R A Olsson
Sep 1, 1973·Circulation Research·E Eikens, D E Wilcken
Oct 1, 1974·Circulation Research·R J BacheJ C Greenfield
May 1, 1972·The Annals of Thoracic Surgery·R S Reneman, M P Spencer
Feb 1, 1973·Circulation Research·M GellaiR Detar
May 1, 1972·Acta Physiologica Scandinavica·S L Nielsen, P Sejrsen
Jan 1, 1980·Acta Physiologica Scandinavica·J K Kristensen, O Henriksen
Dec 1, 1960·The American Journal of Physiology·J D COFFMAN, D E GREGG
Nov 1, 1961·The American Journal of Physiology·J D COFFMAN, D E GREGG
May 1, 1962·The American Journal of Physiology·H V SPARKS, D F BOHR
Feb 1, 1964·Circulation Research·R D JONES, R M BERNE
Dec 1, 1964·Postgraduate Medical Journal·I R GRAYJ H CALDER
Feb 1, 1965·The American Journal of Physiology·R A OLSSON, D E GREGG
May 28, 1902·The Journal of Physiology·W M Bayliss
Apr 14, 1949·Acta Physiologica Scandinavica·B FOLKOW

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.