Regional celiac artery infusion as adjuvant treatment after pancreatic cancer resection

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K LinkH G Beger

Abstract

The dismal course of pancreatic adenocarcinoma patients after resection is determined by the biology of the disease preventing R-0 resections. In the spontaneous course after resection, patients frequently develop either local recurrences, liver metastases and/or peritoneal metastases. Postoperative radiochemotherapy may extend survival and reduce local recurrences without influence on hepatic progression. We performed adjuvant celiac artery infusion in pancreatic cancer, to find out whether this treatment prolongs survival and changes the biology of the disease after resection, especially by reducing liver metastasis. 20 patients received cyclic celiac artery infusions (CAI) after resection of their pancreatic cancer (18 ductal, 2 cystadenocarcinoma). The treatment consisted of 6 cycles intraarterial infusion using Seldinger's technique with mitoxantrone (Novantron, Wyeth-Lederle, Germany) 10 mg/m2 dl, 5-fluorouracil + folinic acid (Fluroblastin, Farmitalia, Germany + Leucovorin, Wyeth-Lederle) 600 mg/m2 + 170 mg/m2 d2-4, and cis-platinum (Cisplatin, Bristol, München, Germany) 60 mg/m2 d5. The patients were monitored for toxicity, development of disease progression and survival. The median survival time was 21 months, and only...Continue Reading

Citations

Feb 25, 2005·AJR. American Journal of Roentgenology·Tsuyoshi TajimaHiroshi Honda
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Asma SultanaPaula Ghaneh
Dec 12, 2007·Best Practice & Research. Clinical Gastroenterology·Michel DucreuxDavid Malka
Mar 22, 2006·Best Practice & Research. Clinical Gastroenterology·Paula GhanehJohn Neoptolemos
Apr 28, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C H van EijckJ Jeekel
May 31, 2012·World Journal of Gastrointestinal Oncology·Kwang Yeol PaikDong Wook Choi
Dec 5, 2003·Alimentary Pharmacology & Therapeutics·S ShoreJ P Neoptolemos
Jun 11, 1999·American Journal of Clinical Oncology·E PelosiA Mussa

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