Regional cerebral blood flow in multiple sclerosis measured by single photon emission tomography with technetium-99m hexamethylpropyleneamine oxime

European Neurology
J LyckeO Andersen

Abstract

The regional cerebral blood flow (rCBF) in 19 patients with multiple sclerosis (MS), 10 with a relapsing remitting course and 9 with a progressive course, was examined by single photon emission computed tomography (SPECT) using technetium-99m hexamethylpropyleneamine oxime ([99mTc]-d,l-HM-PAO) as flow tracer. Nine age-matched volunteers served as controls. Low rCBF in the frontal grey matter correlated with neurological disability (p < 0.01), low frontal grey and white matter perfusion correlated with impaired cognitive functions (p < 0.02), and low rCBF in the occipital regions correlated with impaired visual functions (p < 0.03) in the MS population. A relationship was also found between reduced parietal white matter perfusion and the duration of the disease (p < 0.005). Patients with progressive MS had significantly reduced rCBF in the frontal grey matter compared with relapsing remitting MS patients and controls (p < 0.05). No other rCBF differences were found. As a diagnostic tool in MS, SPECT-[99mTc]-d,l-HM-PAO was found to be insensitive.

Citations

Jun 11, 2011·Journal of Neurology·David PalingDavid Miller
Jan 1, 1996·Electroencephalography and Clinical Neurophysiology·D R ChabollaB F Westmoreland
Apr 9, 2005·Journal of Clinical and Experimental Neuropsychology·Nancy ChiaravallotiJohn DeLuca
Aug 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·W RashidD H Miller
Mar 10, 2009·Neurobiology of Aging·Angela L JeffersonCharles R G Guttmann
Jun 25, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Miguel D'haeseleerMarie B D'hooghe
Jul 3, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jacques De KeyserMarcus W Koch
Sep 14, 2012·Neurological Research·Sandra Morovic, Paolo Zamboni
Jul 1, 2015·BMC Medicine·Sheila TsauSteven M LeVine
Jun 21, 2011·Lancet Neurology·Miguel D'haeseleerJacques De Keyser
Apr 3, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Michael AmannAchim Gass
May 3, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Matilde IngleseRobert I Grossman
Sep 14, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M OkamotoM Imaizumi
Sep 19, 2012·Nature Reviews. Neurology·Valentina TomassiniJacqueline Palace
Jan 6, 2018·AJNR. American Journal of Neuroradiology·E LapointeA Rauscher
Nov 21, 2008·Journal of Neuroscience Research·Akvile NorkuteMarkus Kipp
May 3, 2019·Current Eye Research·Yi LiuJianhua Wang
Feb 1, 1997·Multiple Sclerosis : Clinical and Laboratory Research·C SchiepersH Carton
Apr 21, 2019·Expert Review of Neurotherapeutics·Dejan JakimovskiRobert Zivadinov
Apr 26, 2012·Acta Neurologica Scandinavica·M BlinkenbergP S Sørensen
Jul 18, 2002·Multiple Sclerosis : Clinical and Laboratory Research·N UzunerG Ozdemir
Dec 13, 2019·Translational Neurodegeneration·Jeroen Van SchependomMiguel D'haeseleer
Mar 22, 2019·Biomedicines·Miguel Ángel Macías Islas, Ethel Ciampi
Oct 23, 2019·Neural Regeneration Research·Maria Marcella LaganaFrancesca Baglio
Oct 22, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·R BakshiW R Kinkel
Mar 15, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiroki KatoJun Hatazawa
Jul 4, 2020·Multiple Sclerosis and Related Disorders·Simona LattanziMauro Silvestrini
Mar 7, 2021·International Journal of Molecular Sciences·Angela DziedzicMichal Bijak

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