Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

Neuropsychobiology
S MirzaeiM Pecherstorfer

Abstract

The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls. We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects. Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant. Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

Citations

Apr 14, 2009·Topics in Magnetic Resonance Imaging : TMRI·Jean Théberge
Dec 4, 2004·Biological Psychiatry·Ramón J L LindauerBerthold P R Gersons
Nov 20, 2003·Biological Psychiatry·Omer BonneArieh Y Shalev
Dec 31, 2016·Experimental Neurobiology·Jooyeon Jamie ImSujung Yoon
Sep 12, 2020·The Australian and New Zealand Journal of Psychiatry·Belinda LiddellRichard A Bryant
Oct 9, 2004·Wiener klinische Wochenschrift·Siroos MirzaeiHorst Köhn

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