Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial

PloS One
Mads SvartNiels Moeller

Abstract

Ketone bodies are neuroprotective in neurological disorders such as epilepsy. We randomly studied nine healthy human subjects twice-with and without continuous infusion of 3-hydroxybutyrate-to define potential underlying mechanisms, assessed regionally (parietal, occipital, temporal, cortical grey, and frontal) by PET scan. During 3-hydroxybutyrate infusions concentrations increased to 5.5±0.4 mmol/l and cerebral glucose utilisation decreased 14%, oxygen consumption remained unchanged, and cerebral blood flow increased 30%. We conclude that acute 3-hydroxybutyrate infusion reduces cerebral glucose uptake and increases cerebral blood flow in all measured brain regions, without detectable effects on cerebral oxygen uptake though oxygen extraction decreased. Increased oxygen supply concomitant with unchanged oxygen utilisation may contribute to the neuroprotective effects of ketone bodies.

References

Mar 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S OhtaA Gjedde
Oct 1, 1985·Archives of Gerontology and Geriatrics·S Hoyer
Mar 19, 1970·The New England Journal of Medicine·G F Cahill
Oct 1, 1967·The Journal of Clinical Investigation·O E OwenG F Cahill
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G Blomqvist
Sep 1, 1980·Stroke; a Journal of Cerebral Circulation·J R KirschP B Mongroo
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Jan 1, 1980·Physiological Reviews·A M Robinson, D H Williamson
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SatoR L Veech
Jul 1, 1993·Canadian Journal of Physiology and Pharmacology·A S Chang, L G D'Alecy
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S OhtaA Gjedde
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y KashiwayaR L Veech
Sep 25, 2001·IUBMB Life·R L VeechG F Cahill
Jul 8, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rasmus LindePeter L Madsen
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Andrei G VlassenkoMark A Mintun
May 6, 2008·Lancet Neurology·Elizabeth G NealJ Helen Cross
Nov 3, 2010·Nutrition·Stephen CunnaneStanley I Rapoport
Dec 22, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A Dienel
Dec 18, 2012·Clinical Nuclear Medicine·Kirsten Korsholm, Ian Law
Jun 6, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yifan ZhangMichelle A Puchowicz
Aug 8, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Peter Schönfeld, Georg Reiser
Jan 11, 2014·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Lisa Mosconi
Aug 17, 2014·Aging·Clare EdwardsPatrick C Bradshaw
Sep 10, 2014·Metabolism: Clinical and Experimental·Nadia BouteldjaLars Christian Gormsen
Nov 22, 2014·The Journal of Clinical Endocrinology and Metabolism·Kristian H MikkelsenGerrit van Hall
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Junxiang YinJiong Shi
Sep 18, 2015·The New England Journal of Medicine·Bernard ZinmanUNKNOWN EMPA-REG OUTCOME Investigators
Jun 16, 2016·Cell Metabolism·Valter D Longo, Satchidananda Panda
Oct 16, 2016·Journal of Neurochemistry·Krisztina MarosiMark P Mattson
Feb 18, 2017·Circulation Research·Ulrich FörstermannHuige Li

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Citations

Jun 27, 2018·Medicine and Science in Sports and Exercise·Mark Evans, Brendan Egan
Oct 11, 2019·The American Journal of Clinical Nutrition·Étienne Myette-CôtéJonathan P Little
Feb 6, 2020·Current Pharmaceutical Design·Jeremy J WalshJonathan P Little
Jun 12, 2020·The Journal of Clinical Endocrinology and Metabolism·Niels Møller
Mar 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Katrine M LauritsenLars C Gormsen
Jul 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Nikolaj RittigNiels Jessen
Jan 15, 2019·Intensive Care Medicine·Mauro OddoDavid K Menon
Nov 16, 2019·Medicine and Science in Sports and Exercise·Mark EvansBrendan Egan
Oct 26, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adriano BerniniMauro Oddo
Apr 25, 2020·International Journal of Molecular Sciences·Justyna MierziakJan Szopa
Oct 20, 2020·Endocrine Research·Esben Stistrup LauritzenMette Bjerre
Nov 26, 2020·International Journal of Molecular Sciences·Nicole Jacqueline JensenJørgen Rungby
Apr 15, 2021·Diabetes, Obesity & Metabolism·Esben Thyssen VestergaardHenrik Holm Thomsen
Oct 15, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Hussein N YassineKonrad Talbot
Oct 28, 2021·The Journal of Physiology·Hannah G CaldwellPhilip N Ainslie
Oct 18, 2018·Diabetes Care·Katrine M LauritsenLars C Gormsen

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Methods Mentioned

BETA
biosensor
ELISA

Clinical Trials Mentioned

NCT02357550

Software Mentioned

Stata
Sigmaplot

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