Regional Cerebrovascular Reactivity and Cognitive Performance in Healthy Aging

Journal of Experimental Neuroscience
Sarah J CatchloveAndrew Pipingas

Abstract

Cerebrovascular reactivity (CVR) reflects the response of brain blood vessels to vasoactive stimuli, such as neural activity. The current research assessed age-related changes in regional CVR to 5% CO2 inhalation in younger (n = 30, range: 21-45 years) and older (n = 29, range: 55-75 years) adults, and the contribution of regional CVR to cognitive performance using blood-oxygen-level dependent contrast imaging (BOLD) functional magnetic resonance imaging (fMRI) at 3T field strength. CVR was measured by inducing hypercapnia using a block-design paradigm under physiological monitoring. Memory and attention were assessed with a comprehensive computerized aging battery. MRI data analysis was conducted using MATLAB® and SPM12. Memory and attention performance was positively associated with CVR in the temporal cortices. Temporal lobe CVR influenced memory performance independently of age, gender, and education level. When analyzing age groups separately, CVR in the hippocampus contributed significantly to memory score in the older group and was also related to subjective memory complaints. No associations between CVR and cognition were observed in younger adults. Vascular responsiveness in the brain has consequences for cognition in ...Continue Reading

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References

Dec 1, 1979·Journal of the Neurological Sciences·F YamaguchiM Yamamoto
Jan 1, 1992·International Psychogeriatrics·T H CrookG J Larrabee
Apr 1, 1989·Stroke; a Journal of Cerebral Circulation·T Reich, H Rusinek
Dec 1, 1989·Stroke; a Journal of Cerebral Circulation·Y Tsuda, A Hartmann
Jan 1, 1996·Pharmacology & Therapeutics·R N Kalaria
Dec 13, 2000·International Journal of Geriatric Psychiatry·C JonkerB Schmand
Apr 20, 2001·Progress in Neurobiology·E Farkas, P G Luiten
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hiroshi ItoJun Hatazawa
Apr 4, 2003·International Journal of Geriatric Psychiatry·Celeste A de JagerRobert Clarke
Nov 5, 2003·Nature Reviews. Neuroscience·Mark D'EspositoAdam Gazzaley
Apr 22, 2004·Nature Reviews. Neuroscience·Costantino Iadecola
Dec 24, 2004·Neuroradiology·F H R van der ZandeW H Backes
Dec 17, 2005·Journal of Applied Physiology·Helene Girouard, Costantino Iadecola
Feb 25, 2006·Stroke; a Journal of Cerebral Circulation·Mauro SilvestriniFabrizio Vernieri
Mar 14, 2007·Circulation·John E DeanfieldTon J Rabelink
Apr 5, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Richard G WisePeter Jezzard
Jun 15, 2007·European Neurology·Edoardo VicenziniGian Luigi Lenzi
Jul 17, 2007·NeuroImage·Peter A ChiarelliPeter Jezzard
Aug 7, 2008·Phytotherapy Research : PTR·Andrew PipingasJoseph Nastasi
Apr 24, 2009·NMR in Biomedicine·Uma S YezhuvathHanzhang Lu
Mar 1, 2007·Journal of Clinical Neurology·Soon-Tae LeeYong-Seok Lee
Dec 23, 2009·Brain Research·Susie HeoArthur F Kramer
Feb 23, 2010·Neuro-degenerative Diseases·Jack C de la Torre
Sep 16, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lidia GlodzikMony J de Leon
Nov 6, 2010·Cerebral Cortex·Hanzhang LuDenise C Park
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Jul 23, 2011·Stroke; a Journal of Cerebral Circulation·Philip B GorelickUNKNOWN American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Counci

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Citations

Jan 22, 2019·Climacteric : the Journal of the International Menopause Society·J N BarnesV M Miller
Jul 26, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Brittany IntzandtClaudine J Gauthier
Aug 28, 2019·Brain Sciences·Sara G Aguilar-NavarroGustavo C Román
Nov 24, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kayla B StefanidisMathew J Summers
Mar 16, 2021·Frontiers in Physiology·Emilie SleightMichael J Thrippleton
Mar 16, 2021·Frontiers in Physiology·Alexander D CohenYang Wang
Mar 30, 2021·Anesthesia and Analgesia·Brina SnyderThomas F Floyd
Nov 23, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Moss Y ZhaoGreg Zaharchuk

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Methods Mentioned

BETA
Cognitive Aging

Software Mentioned

MAC
SPSS
VBM8
SPM12
MATLAB
PickAtlas toolbox
WFU

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