Regional changes in cerebral haemodynamics as a result of a visual stimulus measured by near infrared spectroscopy

Proceedings. Biological Sciences
J H MeekS Zeki

Abstract

Near infrared spectroscopy (NIRS) is used to measure global changes in cerebral haemodynamics. We have adapted the technique to measure regional changes in response to a visual stimulus. Ten volunteers were exposed to a computer generated visual stimulus designed to activate a large area of the visual cortex, including V1, V2, V3, V4 and V5. The stimulus was on for 30 s and off for 30 s. Changes in the concentrations of oxyhaemoglobin ([HbO2]) and deoxyhaemoglobin ([Hb]) were measured using a commercial spectrometer (NIRO500), over the occipital cortex. The data were summed over ten cycles. As a control, the experiment was repeated over the frontal cortex. For each subject [HbO2] increased during stimulation, and decreased when the stimulus was off. The mean (+/- s.e.m.) change in [HbO2] was 0.54 +/0 0.14 micromol 1(-1). The change in total haemoglobin concentration, given by [HbO2] + [Hb] was 0.61 +/- 0.21 micromol 1(-1), equivalent to a rise in cerebral blood volume of 0.04 +/- 0.01 ml 100 g(-1) which is about 2% of the total cerebral blood volume. There was no significant change in [HbO2] over the frontal cortex, implying that the changes in blood volume originated in the occipital lobe. This demonstrates that NIRS provides ...Continue Reading

References

Sep 1, 1977·Journal of Neurophysiology·J S BaizerB M Dow
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·K K KwongR Turner
Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S OgawaK Ugurbil
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J PrichardR Shulman
May 23, 1985·Nature·D H Hubel, M S Livingstone
Aug 1, 1986·Critical Care Medicine·C A PiantadosiF F Jöbsis-Vandervliet
Oct 5, 1986·Nature·P T FoxD C Van Essen
Jul 1, 1982·Electroencephalography and Clinical Neurophysiology·H PrattE Berliner
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T KatoT Ozaki
Mar 1, 1993·Medical Physics·S R ArridgeD T Delpy
Feb 1, 1993·Applied Optics·J C SchotlandJ S Leigh

❮ Previous
Next ❯

Citations

Jan 21, 2010·Experimental Brain Research·Tiina NäsiPekka Meriläinen
Jan 28, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dongmei ZhuHanrong Wu
Oct 6, 2001·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·G Gratton, M Fabiani
Mar 11, 2000·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·H ObrigA Villringer
Jul 17, 1999·Progress in Neurobiology·P L Madsen, N H Secher
May 30, 2002·Magnetic Resonance Imaging·A P BornH C Lou
Mar 17, 2007·The Clinical Neuropsychologist·Patricia M ArenthMaria T Schultheis
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E GrattonM Fabiani
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H R HeekerenA Villringer
Apr 26, 2005·Journal of Biomedical Optics·Enrico GrattonAndrew Webb
Jul 6, 2007·Biomedical Engineering Online·Luigi RovatiSergio Fonda
Jun 8, 2002·Biomedizinische Technik. Biomedical Engineering·G LitscherE Huber
Aug 3, 2013·Sleep Medicine Reviews·Karinna L FyfeRosemary S C Horne
May 1, 2009·IEEE Transactions on Bio-medical Engineering·Sergül AydöreAta Akin
Mar 1, 2005·American Journal of Ophthalmology·Atsushi MikiGrant T Liu
Mar 15, 2006·Pain·Marco BartocciK J S Anand
Jan 25, 2011·Brain Research Bulletin·Ujwal ChaudharyAnuradha Godavarty
Jun 11, 1998·Pediatric Research·J H MeekJ S Wyatt
Jul 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R WenzelA Villringer
May 7, 2004·Physics in Medicine and Biology·Francesco FabbriSergio Fantini
Aug 8, 2018·Annals of the New York Academy of Sciences·Paola PintiPaul W Burgess
Jul 21, 2016·Journal of Biomedical Optics·Manish BhattPhaneendra K Yalavarthy
Dec 20, 2016·Journal of Biomedical Optics·Anne GallagherPhetsamone Vannasing
Sep 13, 2006·Journal of Biomedical Optics·Juliette SelbDavid A Boas
Jun 10, 2010·Physics in Medicine and Biology·F Orihuela-EspinaG Z Yang
Feb 21, 2009·The European Physical Journal. E, Soft Matter·J HegsethD Beysens

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
H HeekerenA Villringer
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
T KatoT Ozaki
© 2021 Meta ULC. All rights reserved