PMID: 9655597Jul 9, 1998Paper

Regional changes of NADPH-diaphorase and neuropeptide Y neurons in the cerebral cortex of aged Fischer 344 rats

Neuroscience Letters
Y HuhH Ahn

Abstract

This study examined the effects of aging on neuropeptide Y (NPY) and NADPH-diaphorase (NADPH-d)-positive neurons of the cerebral cortex in young (3 months) and aged (24 months) Fischer 344 rats by immunohistochemical and histochemical methods. In the aged group, the number of NPY-immunoreactive (IR)/NADPH-d-positive neurons was not significantly changed in all regions of the cerebral cortex compared to the control group. However, the number of NPY-IR/NADPH-d-negative neurons was significantly decreased in frontal association, primary motor, secondary somatosensory, insular, ectorhinal, perirhinal and auditory cortex in the aged group. In the aged rats, about 5-10% of NPY-IR/NADPH-d-positive neurons were dystrophic and scattered within the cerebral cortex. These results suggested that NPY-IR neurons that do not contain NADPH-d are affected by aging and that aging influences NPY-IR/NADPH-d-negative neurons in a region-specific pattern within the cerebral cortex of rats.

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Citations

May 18, 2010·Journal of Molecular Histology·Seung-Jun Hwang, Youngbuhm Huh
May 3, 2003·Neuroscience Research·Alicia VillenaIgnacio Pérez de Vargas
Oct 14, 2004·Microscopy Research and Technique·María Luisa Del MoralMaría Angeles Peinado
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Junyang JungYoungbuhm Huh
Oct 30, 2016·Experimental Gerontology·Pedro A PereiraM Dulce Madeira
Aug 28, 2007·Microscopy Research and Technique·Daniel Sánchez-ZuriagaMaria Rosa Peris-Sanchis
Jan 18, 2006·Microscopy Research and Technique·Florentina DíazIgnacio Pérez De Vargas
May 20, 2021·The Journal of Comparative Neurology·Bárbara de Paula Pires Franco GuimaraesRicardo Gattass

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