Regional chemotherapy: a focus on hepatic artery infusion for colorectal cancer liver metastases

Surgical Oncology Clinics of North America
Don S DizonNancy E Kemeny

Abstract

Regional infusion strategies have been used as a treatment modality in multiple cancers, including ovarian, appendiceal, and colorectal cancers. Perhaps the most illustrative use of regional therapy is that of hepatic arterial infusion (HAI) for liver metastases from colorectal cancer. The administration of chemotherapy by HAI is logical and has theoretic advantages over systemic chemotherapy for the treatment of hepatic metastases from colorectal cancer. With the use of an appropriately chosen chemotherapy agent, HAI can generate an increase in hepatic tumor drug exposure as compared with intravenous delivery of the same agent. This article reviews the pharmacologic benefits of HAI therapy and the contemporary trials performed and underway.

References

Jun 1, 1979·The British Journal of Surgery·J M Northover, J Terblanche
Feb 1, 1987·Journal of Surgical Oncology·L M de BrauwA Zwaveling
Jun 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·W W EckmanJ D Fenstermacher
Apr 16, 2002·Seminars in Oncology·William D Ensminger
Feb 8, 2003·Lancet·David J KerrUNKNOWN European Organisation for Research and Treatment of Cancer colorectal cancer study group
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J M G H van RielG Giaccone
Feb 18, 2005·The New England Journal of Medicine·Nancy E Kemeny, Mithat Gonen
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy KemenyYuman Fong
Jul 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michel DucreuxUNKNOWN gastrointestinal group of the Federation Nationale des Centres de Lutte Contre le Cancer
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E KemenyRobert J Mayer

❮ Previous
Next ❯

Citations

Apr 30, 2011·World Journal of Gastrointestinal Oncology·Joseph SgourosAnthony Maraveyas
Mar 29, 2016·The Surgical Clinics of North America·Heather L Lewis, Mark Bloomston
Apr 21, 2010·The Cancer Journal·Thorvardur R HalfdanarsonAxel Grothey
Oct 12, 2012·Clinical & Experimental Metastasis·Harold J WaneboNancey E Kemeny
Aug 3, 2020·Annals of Surgical Oncology·Brian C BrajcichRyan P Merkow
Oct 8, 2020·AJR. American Journal of Roentgenology·Benjamin S StrnadVincent M Mellnick
Jan 1, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Florian E BuismanMichael I D'Angelica
Jan 21, 2021·Pharmaceutics·Adriana G Quiroz-ReyesElsa N Garza-Treviño
Dec 5, 2017·Current Problems in Surgery·Jeffrey ChakedisTimothy M Pawlik
Feb 25, 2020·Advanced Drug Delivery Reviews·A L B SeynhaeveT L M Ten Hagen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.