Regional comparison of midwall segment and area shortening in the canine left ventricle

Circulation Research
W Y Lew, M M LeWinter

Abstract

We used ultrasonic segment length gauges to examine the regional behavior of midwall fibers at different sites around the left ventricular minor axis in 12 anesthetized dogs. In six dogs (group I) with circumferentially oriented midwall gauges, significantly greater shortening of anterior than lateral or posterior wall segments was demonstrated over a range of left ventricular end-diastolic pressures from 2 to 18 mm Hg. Normalized end-diastolic segment lengths increased more in the anterior wall as end-diastolic pressure increased, suggesting that regional differences in diastolic distensibility may in part account for the observed shortening differences. To examine the extent to which shortening of longitudinally oriented fibers of the subendocardium and subepicardium might influence the behavior of the midwall circumferential fibers, we implanted mutually perpendicular midwall gauges circumferentially and longitudinally in the anterior and posterior walls in six dogs (group II). Longitudinal shortening of midwall fibers was negligible at low end-diastolic pressures, but increased significantly at higher end-diastolic pressures. In the anterior wall, there was greater circumferential than longitudinal shortening, whereas, in t...Continue Reading

References

Sep 1, 1976·The American Journal of Cardiology·K L GouldH T Dodge
Jan 1, 1979·Annals of Biomedical Engineering·T ArtsP C Veenstra
Jun 1, 1978·The American Journal of Cardiology·A A BoveJ F Spann
Apr 1, 1973·The American Journal of Cardiology·A D SnidermanE L Fallen
Dec 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·M P KayeJ Coyle
May 1, 1971·The American Journal of Cardiology·Y KongH D McIntosh
Mar 1, 1980·Medical & Biological Engineering & Computing·R M HuismanG Elzinga
Mar 1, 1981·British Heart Journal·E ShapiroD G Gibson

Citations

Jan 1, 1988·Progress in Biophysics and Molecular Biology·P J Hunter, B H Smaill
Apr 1, 1991·Journal of the American College of Cardiology·T TakahashiW Grossman
May 1, 1993·Journal of the American College of Cardiology·Y GotoH Suga
Jul 1, 1994·Acta Physiologica Scandinavica·S Birkeland, E Hexeberg
Aug 28, 2010·International Journal of Peptides·Ichiro Sakata, Takafumi Sakai
Dec 12, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sushil A LuisJonathan Chan
May 23, 2008·International Journal of Cardiology·Akira MatsukiHiroshi Inoue
Nov 1, 1987·American Heart Journal·N E FarberG J Gross
Nov 2, 2011·Peptides·John P VuJoseph R Pisegna
Apr 2, 2011·Expert Review of Cardiovascular Therapy·Rajesh Janardhanan, Christopher M Kramer
Sep 1, 1988·Basic Research in Cardiology·L Hittinger, B Crozatier
Apr 11, 2018·Journal of Elasticity·Colleen M Witzenburg, Jeffrey W Holmes
Feb 9, 2000·American Journal of Physiology. Heart and Circulatory Physiology·P ZhuG G Schwartz

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