PMID: 6401374Jan 1, 1983Paper

Regional coronary blood flow during relief of pacing-induced angina by nitroglycerin. Implications for mechanism of action

The American Journal of Cardiology
R M FuchsF C Yin

Abstract

The mechanism for the therapeutic effect of nitroglycerin in stress-induced angina remains controversial; it has been attributed to both increased blood supply to the ischemic myocardium and decreased myocardial oxygen demand. To investigate the contribution of each of these mechanisms, systemic pressures and great cardiac vein flow were measured in 14 patients with single-vessel disease involving the left anterior descending (LAD) coronary artery during the development of pacing-induced angina and after the administration of nitroglycerin while continuing pacing at the angina-provoking rate. Great cardiac vein flow, measured by thermodilution, represents the venous efflux from the LAD territory and therefore provided an index of flow to the poststenotic myocardium. In 11 patients, nitroglycerin was administered systemically (400 to 800 micrograms sublingually or 200 micrograms intravenously); angina was relieved in 10, concomitant with a decrease in both great cardiac vein flow (from 123 +/- 29 to 98 +/- 29 ml/min, p less than 0.001) and mean aortic pressure (from 118 +/- 22 to 104 +/- 22 mm Hg, p less than 0.001). In contrast, when 75 micrograms of nitroglycerin was administered directly into the left main coronary artery of ...Continue Reading

References

May 1, 1968·Circulation Research·W M Fam, M McGregor
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Citations

Jan 1, 1986·Current Problems in Cardiology·M J Kern, J T Miller
Jun 4, 1990·The American Journal of Cardiology·A Schneeweiss, L Reisin
Nov 15, 1990·Biochemical Pharmacology·R F BoothJ Dickens
Nov 6, 2001·Journal of the American College of Cardiology·A OkamuraT Ogihara
Aug 1, 1987·Journal of the American College of Cardiology·L W KleinR H Helfant
Nov 1, 1987·The American Journal of Medicine·S SilberK Theisen
May 1, 1988·Circulation Research·T W LatsonK Sagawa
Jan 1, 1990·International Journal of Cardiac Imaging·S JostI Knop
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·A Raedler, S Schreiber

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