Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies: Associations with clinical severity, glucose metabolism and tau PET

NeuroImage. Clinical
Zuzana NedelskaKejal Kantarci

Abstract

Visually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign, is a feature of dementia with Lewy bodies (DLB) on FDG-PET. Lower cingulate island sign ratio (posterior cingulate cortex/cuneus+precuneus; FDG-CISr) values have been associated with a higher Braak neurofibrillary tangle stage in autopsied DLB. Using voxel-wise analysis, we assessed the patterns of regional cortical perfusion and metabolism, and using an atlas-based approach, we measured perfusion cingulate island sign ratio on arterial spin labeling MRI (ASL-CISr), and its associations with FDG-CISr, uptake on tau-PET and clinical severity in DLB. Our study sample (n = 114) included clinically probable DLB patients (n = 19), age-matched patients with probable Alzheimer's disease dementia (AD; n = 19) and matched controls (n = 76) who underwent MRI with 3-dimensional pseudo-continuous arterial spin labeling, 18F-FDG-PET and 18F-AV-1451 tau PET. Patterns of cortical perfusion and metabolism were derived from quantitative maps using Statistical Parametric Mapping. DLB patients showed hypoperfusion on ASL-MRI in precuneus, cuneus and posterior parieto-occipital cortices, compared to controls, a...Continue Reading

Citations

May 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Zuzana Nedelska, Kejal Kantarci
Dec 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Yonglu ChenBiao Huang
Oct 13, 2020·Frontiers in Neurology·Annie G BryantRachel E Bennett
Oct 22, 2020·Journal of Neurology·Michael J FirbankAlan J Thomas
Jun 16, 2021·Neurobiology of Aging·Daniel FerreiraKejal Kantarci

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Software Mentioned

R
ASL
SAS
CISr
Statistic Parametric Mapping

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