Regional decreases [corrected] in AMPA receptor density in mice infected with the LP-BM5 murine leukemia virus

Neuroreport
Y KustovaA S Basile

Abstract

The status of alpha-amino-3-hydroxy-5-methyl-4-isoxizole (AMPA) receptors in several brain regions was investigated in a murine model of retrovirus-associated cognitive impairment, the LP-BM5 infected mouse. The Bmax of [3H]AMPA receptors in the cortex, striatum, hippocampus and cerebellum declined by 29-50% as early as 8 weeks post-inoculation. Immunohistochemistry revealed foci of decreased glutamate receptor (GluR)-2/3 protein expression by Purkinje neurons distributed throughout the cerebellum. Immunoblots indicated that cerebellar expression of only GluR-3 protein was reduced. This global decrease in AMPA receptors may constitute a compensatory response to elevated excitotoxin (glutamate) concentrations and are concurrent with the development of spatial learning deficits observed in these mice. Thus, the reduction in AMPA receptor density may contribute to the development of the cognitive abnormalities associated with infection by retroviruses such as HIV-1.

References

Nov 1, 1992·Journal of Neurobiology·D W Choi
Apr 15, 1992·The Journal of Comparative Neurology·R S Petralia, R J Wenthold
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·U StaubliG Lynch

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Citations

Mar 20, 2001·The Journal of Clinical Investigation·E KoustovaA S Basile
May 29, 2014·Journal of Neurovirology·Fabián J Vázquez-SantiagoVanessa Rivera-Amill
May 27, 1999·Molecular and Chemical Neuropathology·Y KustovaA S Basile
Apr 23, 2008·Current Protocols in Neuroscience·Yoshitatsu Sei, Anthony S Basile
Feb 22, 2008·Molecular Diagnosis & Therapy·Alireza MinagarPaul Shapshak
Dec 14, 2001·Neurobiology of Disease·A S BasileP N Usherwood

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