PMID: 3930004Oct 21, 1985Paper

Regional depletion of central nervous system catecholamines: effects on blood pressure and drinking behavior

Brain Research
F J GordonA K Johnson

Abstract

The purpose of the present study was to identify which catecholamine-containing neurons (norepinephrine (NE) or dopamine (DA)) and which central nervous system (CNS) region(s) innervated by them might participate in the pressor and drinking responses produced by central drug stimulation. Forebrain NE was reduced in rats by injecting 4 micrograms of 6-hydroxydopamine (6-OHDA) into the ascending noradrenergic bundles. Spinal cord NE was depleted by intracisternal injection of 50 micrograms 6-OHDA. Depletion of forebrain DA was produced by bilateral injection of 4 micrograms 6-OHDA into the substantia nigra of desipramine-pretreated rats. Pressor responses to various doses of angiotensin II (AII), carbachol or hyperosmolar NaCl injected into the lateral ventricles (LVT); and drinking responses to LVT AII and carbachol were examined. Injection of 6-OHDA into the noradrenergic bundles reduced telencephalic and hypothalamic NE by more than 80% without significantly affecting brain DA or spinal cord NE. Intracisternal 6-OHDA depleted spinal cord NE by 80% and forebrain NE by 20-25% without reducing brain DA. Injection of 6-OHDA into the substantia nigra reduced telencephalic DA by 86% and NE by 29% without significantly affecting NE i...Continue Reading

References

May 1, 1978·Pharmacology, Biochemistry, and Behavior·D M Jacobowitz, J S Richardson
Sep 1, 1977·Neuropharmacology·W E HoffmanP Schmid
Jan 1, 1975·Biochemical Pharmacology·C Sachs, G Jonsson
Feb 1, 1976·Journal of Comparative and Physiological Psychology·E M Stricker
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Sep 3, 1973·JAMA : the Journal of the American Medical Association·P W Rogers, N A Kurtzman
Nov 1, 1974·Journal of Comparative and Physiological Psychology·J F MarshallP Teitelbaum
Jan 1, 1972·Physiology & Behavior·G A Oltmans, J A Harvey
May 1, 1973·Pharmacology, Biochemistry, and Behavior·G R BreeseL D Grant
Jun 1, 1974·Journal of Comparative and Physiological Psychology·E M Stricker, M J Zigmond
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Kirk
Jan 1, 1984·European Journal of Clinical Pharmacology·E Müller-Schweinitzer

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Citations

Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E ColombariJ V Menani
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·J C CalleraW A Saad
Jan 1, 1994·Neuroscience and Biobehavioral Reviews·J W Wright, J W Harding
Jan 1, 1989·Brain Research. Brain Research Reviews·S M Gardiner, T Bennett
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·A K JohnsonR L Thunhorst
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·T A JenkinsF A Mendelsohn
Sep 30, 2000·Journal of Neurosurgery·K Al MoutaeryM Tariq
Apr 11, 2021·Physiology & Behavior·Elizabeth G Mietlicki-BaaseDerek Daniels

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