PMID: 9555574Apr 29, 1998Paper

Regional deposition of inhaled Evans blue dye in mechanically ventilated rabbits with air or helium oxygen mixture

Experimental Lung Research
M SvartengrenM Dahlbäck

Abstract

An animal model has been used and further developed to examine and evaluate differences in regional deposition patterns of an Evans Blue dye (EB) tracer aerosol. This was done by using different carrier gas composition of either He-O2 (80% helium, 20% oxygen) or air (79% nitrogen, 21% oxygen) in histamine-provoked and nonprovoked rabbits. The ratio of peripheral deposition to total deposition (central + peripheral), in relation to percentage increase in intratracheal pressure (ITP delta %), was used as an evaluation tool. The animals were tracheostomized, cannulated, and ventilated in a volume-controlled mode until they were stable. Saline or histamine was then administrated for 2 min before the tracer aerosol EB was given. The percentage increase in intratracheal pressure before and after provocation was calculated (ITP delta %) and was, on average, 51 +/- 20% for air and 51 +/- 20% for He-O2. EB was extracted from lung tissues and measured with a spectrophotometer. The absorbance in different lung regions was used as a measure of the distribution of aerosol. Bronchial provocation gave a central deposition 0.55 +/- 0.11 (mean +/- SD, ratio = peripheral deposition/central + peripheral deposition) compared to 0.80 +/- 0.09 in th...Continue Reading

References

Dec 1, 1991·Journal of Applied Physiology·M SvartengrenP Camner
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Oct 1, 1981·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N L Muller, N Zamel
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Dec 4, 1994·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M DahlbäckB Jonson

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Citations

Oct 25, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Ann TrondeUrsula Hultkvist Bengtsson
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Shamel A Abd-AllahRonald M Perkin
Jan 5, 2014·Journal of Aerosol Medicine and Pulmonary Drug Delivery·I KatzG Caillibotte
Jan 1, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Chantal Darquenne, G Kim Prisk

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