Abstract
Treatment approaches for hepatocellular carcinoma (HCC) vary across countries, but these differences and their potential impact on outcomes have not been comprehensively assessed. Data from the multinational GIDEON (Global Investigation of therapeutic DEcisions in HCC and Of its treatment with sorafeNib) registry evaluated differences in patient characteristics, practice patterns and outcomes in HCC across geographical regions in patients who received sorafenib. GIDEON is a non-randomised, observational registry study conducted in 39 countries across five global regions. HCC patients in whom a decision to treat with sorafenib was made in clinical practice and according to local practices were included. 3202 patients were evaluable for safety analysis: Asia-Pacific (n = 928), Japan (n = 508), Europe (n = 1113), USA (n = 563) and Latin America (n = 90). Patients in Japan had earlier-stage disease at initial diagnosis compared with patients in other regions (Barcelona Clinic Liver Cancer stage A; 43.7% vs 9.1-24.3%). Use of locoregional therapies before sorafenib, including transarterial chemoembolisation, was more common in Japan (84.4%) and Asia-Pacific (67.2%) compared with the USA (49.4%) and Europe (43.5%). Treatment patterns...Continue Reading
References
Jun 16, 2007·Gastroenterology·Hashem B El-Serag, K Lenhard Rudolph
Jul 19, 2008·World Journal of Gastroenterology : WJG·Abdel-Rahman El-Zayadi
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 20, 2008·The Lancet Oncology·Ann-Lii ChengZhongzhen Guan
Jan 15, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Puneeta Tandon, Guadalupe Garcia-Tsao
Jul 21, 2010·International Journal of Clinical Practice·R LencioniM Kudo
Jan 18, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E Maillard
Feb 4, 2012·Journal of Hepatology·Carlos Rodríguez de LopeJordi Bruix
Mar 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·UNKNOWN European Association for Study of Liver, UNKNOWN European Organisation for Research and Treatment of Cancer
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Apr 28, 2012·Gastroenterology·Hashem B El-Serag
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jing GaoYong-Bing Xiang
Jun 16, 2012·International Journal of Clinical Practice·R LencioniJ A Marrero
Aug 1, 2012·Seminars in Oncology·Riccardo Lencioni
Jun 6, 2014·Clinical Medicine Insights. Oncology·Avegail Flores, Jorge A Marrero
Citations
Aug 24, 2016·Journal of Gastroenterology·Masatoshi KudoAndrew Xiuxuan Zhu
Jan 25, 2017·Alimentary Pharmacology & Therapeutics·D J PinatoR Sharma
Nov 22, 2016·The Cancer Journal·Lin MuJean-François Geschwind
Jun 18, 2017·Hepatology International·Masao OmataShiv Kumar Sarin
Jun 24, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Jose D DebesLewis R Roberts
Sep 12, 2017·Investigational New Drugs·Sadahisa OgasawaraNaoya Kato
Dec 14, 2017·Liver Cancer·Clarence YenDavid James Pinato
Dec 14, 2017·Liver Cancer·Masatoshi Kudo
Apr 24, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shinsuke UchikawaKazuaki Chayama
Jul 12, 2018·Investigational New Drugs·Masafumi IkedaDaisuke Sakai
Aug 1, 2018·Nature Reviews. Clinical Oncology·Josep M LlovetRichard S Finn
Mar 5, 2020·PloS One·Jonggi ChoiHan Chu Lee
Mar 17, 2017·Targeted Oncology·Gillian M Keating
Oct 19, 2016·AIDS·Nicolás MerchanteUNKNOWN GEHEP-002 Study Group
Jul 6, 2018·Gene Therapy·Chuan TianWei Song
Dec 24, 2018·Expert Review of Anticancer Therapy·Bernard EscudierMasatoshi Kudo
Dec 14, 2018·Investigational New Drugs·Changhoon YooHo Yeong Lim
Oct 13, 2018·World Journal of Hepatology·Issei SaekiIsao Sakaida
Aug 17, 2018·JMIR Research Protocols·Nikhil ChauhanRiad Salem
Aug 14, 2020·Future Oncology·Laura L de GuevaraMasatoshi Kudo
Feb 29, 2020·Journal of Gastroenterology·Masatoshi KudoAndrew X Zhu
Apr 25, 2020·Journal of Medical Ultrasonics·Kazushi Numata
Aug 13, 2020·Signal Transduction and Targeted Therapy·Ao HuangJian Zhou
Nov 11, 2017·Expert Review of Gastroenterology & Hepatology·Yousery NadaOmar Abdel-Rahman
Apr 8, 2020·Cancer Prevention Research·Mozhdeh SojoodiBryan C Fuchs
Dec 10, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Hidenori ToyodaAmit G Singal
Aug 20, 2021·Hepatic Oncology·Abdalla AlyBrian Seal