PMID: 9423834Jan 10, 1998Paper

Regional differences in the cellular immune response to experimental cutaneous or visceral infection with Leishmania donovani

Infection and Immunity
P C MelbyW Zhao

Abstract

Infection with the protozoan Leishmania donovani can cause serious visceral disease or subclinical infection in humans. To better understand the pathogenesis of this dichotomy, we have investigated the host cellular immune response to cutaneous or visceral infection in a murine model. Mice infected in the skin developed no detectable visceral parasitism, whereas intravenous inoculation resulted in hepatosplenomegaly and an increasing visceral parasite burden. Spleen cells from mice with locally controlled cutaneous infection showed strong parasite-specific proliferative and gamma interferon (IFN-gamma) responses, but spleen cells from systemically infected mice were unresponsive to parasite antigens. The in situ expression of IFN-gamma, interleukin-4 (IL-4), IL-10, IL-12, and inducible nitric oxide synthase (iNOS) mRNAs was determined in the spleen, draining lymph node (LN), and cutaneous site of inoculation. There was considerably greater expression of IFN-gamma and IL-12 p40 mRNAs in the LN draining a locally controlled cutaneous infection than in the spleen following systemic infection. Similarly, there was a high level of IFN-gamma production by LN cells following subcutaneous infection but no IFN-gamma production by spleen...Continue Reading

References

Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·F P HeinzelR M Locksley
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Jun 1, 1989·The Journal of Clinical Investigation·P C MelbyD L Sacks
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K AssoianM B Sporn
Jun 1, 1988·The Journal of Experimental Medicine·M J McElrathZ A Cohn
Dec 1, 1986·The Journal of Infectious Diseases·R BadaroW D Johnson
Dec 1, 1985·The Journal of Clinical Investigation·E M CarvalhoW D Johnson
Jan 1, 1974·Transactions of the Royal Society of Tropical Medicine and Hygiene·S PampiglioneG Canestri Trotti
Aug 1, 1995·European Journal of Immunology·T LaskayW Solbach
Oct 1, 1994·Scandinavian Journal of Immunology·M ViethA Gessner
May 1, 1993·The Journal of Experimental Medicine·F P HeinzelM K Gately
Jul 1, 1993·Immunology Today·G Trinchieri
Mar 1, 1994·Infection and Immunity·G D MirallesH W Murray
Sep 1, 1996·FEMS Immunology and Medical Microbiology·P C MelbyG Valencia-Pacheco

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Citations

Apr 6, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H Goto, J A L Lindoso
Oct 3, 2006·Apoptosis : an International Journal on Programmed Cell Death·Piyali MukherjeeAsoke C Ghose
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mukesh SamantAnuradha Dube
Feb 2, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Teixeira, R Gomes
Apr 1, 2015·PLoS Neglected Tropical Diseases·Estefanía Calvo-ÁlvarezRosa M Reguera
May 31, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ayse CanerAyfer Haydaroğlu
Aug 6, 2002·The Journal of Biological Chemistry·Funmei YangDavid J Haile
Jul 14, 2001·Antimicrobial Agents and Chemotherapy·H W Murray
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Henry W Murray
Nov 13, 2001·International Journal of Experimental Pathology·H W Murray
Apr 25, 2006·Parasite Immunology·J CarriónC Alonso
Oct 16, 2004·Expert Review of Anti-infective Therapy·Henry W Murray
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Regis GomesCláudia I Brodskyn
Jan 21, 2012·Journal of Biomedicine & Biotechnology·T P Velavan, Olusola Ojurongbe
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J A StreitM E Wilson
Feb 21, 2007·Parasitology Research·Kishor PandeyHiroji Kanbara
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Henry W MurrayFrederick P Heinzel
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·Michael Zhuo WangKarl A Werbovetz
Jan 10, 2013·PLoS Pathogens·Laura-Isobel McCallGreg Matlashewski
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monidipa GhoshSantu Bandyopadhyay
Mar 21, 2007·Parasite Immunology·M P QuinonesS S Ahuja
Dec 24, 2002·Infection and Immunity·Saeed AhmedDiane McMahon-Pratt

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