Regional differences in the distribution of gonadotropin-releasing hormone cells between rapidly growing and growth-restricted prepubertal female sheep

Endocrinology
H I'AnsonD L Foster

Abstract

Growth retardation induced by dietary restriction in the lamb results in a low GnRH pulse frequency, and thus, puberty is delayed. In our experimental model, in which ovariectomized lambs are maintained at weaning weight (approximately 20 kg BW), hypothalamic GnRH is present and releasable, suggesting that central mechanisms limit the release of GnRH during chronic growth restriction. Our study compared the number and distribution of GnRH-containing neurons in growth-restricted (n = 5) and rapidly growing (n = 5) ovariectomized prepubertal female lambs at 24 weeks of age (normal age of puberty is about 30 weeks). Immunoreactive cells were labeled using LR-1 antiserum (R. Benoit) and an avidin-biotin-immunoperoxidase procedure. GnRH neurons were localized in 60-micron coronal sections from the level of the diagonal band of Broca to the mammillary bodies. The estimated total number of GnRH neurons in the growth-restricted and rapidly growing lambs was similar (3364.8 +/- 513.8 vs. 3151.2 +/- 279.8, respectively). In addition, the percent distributions of GnRH neurons in the diagonal band of Broca, the anterior hypothalamus, the lateral hypothalamus, and the posterior hypothalamus were not different. A trend (P = 0.07) toward a sm...Continue Reading

Citations

Feb 14, 2012·Animal Reproduction Science·I ValasiG S Amiridis
Jan 13, 2015·Veterinary Parasitology·G C FthenakisE Papadopoulos
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George N Wade, Juli E Jones
Aug 25, 2007·Molecular Endocrinology·Tiziana CogliatiIlan R Kirsch
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Aug 2, 2008·Reproduction, Fertility, and Development·Jun YanGuoliang Xia
Nov 20, 2016·Annals of the New York Academy of Sciences·Elissa Z CameronLaura M Parsley

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