Regional differences in the effect of mucosal glucose and amino acids on ion transport in normal and cholera toxin-stimulated porcine small intestine

Scandinavian Journal of Gastroenterology
M L GrøndahlE Skadhauge

Abstract

This study explores regional differences in the response to mucosal D-glucose and L-amino acids in both normal intestine and intestine stimulated with cholera toxin. Proximal, mid and distal small intestines from 6- to 8-week-old pigs were bathed in Ussing chambers with a buffer containing 15 mM serosal glucose, and the effect of adding a cocktail giving luminal chamber concentrations of 15 mM D-glucose and 20 mM of each L-alanine, L-proline, L-lysine, L-phenylalanine, and L-glutamine on transmucosal Na+ and Cl- transport was measured. In all segments of both normal and cholera toxin-treated intestine, electrogenic Na+ and electroneutral NaCl absorption were promoted. No significant differences in the net increase of Na+ and Cl- absorption between normal and cholera toxin-stimulated intestine were present. Under both conditions no segmental differences were present in the stimulated Cl- absorption, describing identical capacity for stimulated electroneutral NaCl absorption. In contrast the electrogenic Na+ absorption was, compared to the proximal part, doubled in the mid and distal parts under both conditions. We conclude that mucosal D-glucose and L-amino acids stimulate electroneutral NaCl and electrogenic Na+ absorption to t...Continue Reading

References

Apr 1, 1991·Zentralblatt für Veterinärmedizin. Reihe A·G T McEwanE Skadhauge
May 1, 1988·The Journal of Membrane Biology·W ClaussE Skadhauge
Jan 1, 1987·The Journal of Membrane Biology·J L Madara, J R Pappenheimer
Apr 1, 1968·The American Journal of Physiology·A E TaylorP F Curran
Jan 1, 1994·Annual Review of Nutrition·J F DesjeuxJ Taminiau
Mar 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·M B HansenE Skadhauge

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Citations

Jul 29, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Richard L GuerrantRebecca A Dillingham
Dec 2, 2017·Journal of Animal Physiology and Animal Nutrition·K BlaabjergH D Poulsen

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