Regional differences in the management and outcome of kidney transplantation in patients with human immunodeficiency virus infection: A 3-year retrospective cohort study

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Marina P CristelliSao Paulo-Barcelona Renal Transplant in HIV Investigators

Abstract

In the developed world, kidney transplantation (KT) in patients with human immunodeficiency virus (HIV) infection is well established. Developing countries concentrate 90% of the people living with HIV, but their experience is underreported. Regional differences may affect outcomes. We compared the 3-year outcomes of patients with HIV infection receiving a KT in two different countries, in terms of incomes and development. This was an observational, retrospective, double-center study, including all HIV-infected patients >18 years old undergoing KT. Between 2005 and 2015, 54 KTs were performed (39 in a Brazilian center, and 15 in a Spanish center). Brazilians had less hepatitis C virus co-infection (5% vs 27%, P=.024). Median cold ischemia time was higher in Brazil (25 vs 18 hours, P=.001). Biopsy-proven acute rejection (AR) was higher in Brazil (33% vs 13%, P=.187), as were the number of AR episodes (22 vs 4, P=.063). Patient survival at 3 years was 91.3% in Brazil and 100% in Spain; P=.663. All three cases of death in Brazil were a result of bacterial infections within the first year post transplant. At 3 years, survival free from immunosuppressive changes was lower in Brazil (56% vs 90.9%, P=.036). Raltegravir-based treatment...Continue Reading

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Citations

May 17, 2019·Current HIV/AIDS Reports·William A Werbel, Christine M Durand
May 11, 2020·Pediatric Transplantation·Fatina I FadelDoaa M Salah
Nov 22, 2019·AIDS Research and Therapy·Xin ZhengXiaopeng Hu
Nov 21, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Christina D MejiaDong Heun Lee

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