PMID: 6107345Oct 1, 1980Paper

Regional differences in the responses to prostanoids of circular muscle from guinea-pig isolated intestine

The Journal of Pharmacy and Pharmacology
G J Sanger, A Bennett

Abstract

The effects of prostaglandins (PGs) D2, E2, F2 alpha, an epoxymethano analogue of PGH2 (U-46619), prostacyclin (PGI2), 6-keto-PGF1 alpha and thromboxane (TX) B2 were tested on spirally-cut strips of guinea-pig isolated ileum or colon. In the ileum no prostanoid exerted a marked effect on the resting tissue, but PGD2, PGE2 or PGI2 1 ug ml-1 inhibited submaximal contraction to KC1. U-46619 1 ug ml-1 either inhibited or increased contractions in KC1, but PGF2 alpha, 6-keto-PGF1 alpha or TXB2 1 ug ml-1 had no significant effect. PGE2 relaxed colonic strips whereas the other prostanoids caused contraction, except for TXB2 which had no effect. The PG antagonist SC-19220 blocked colonic contractions to the prostanoids, and the residual inhibitory effect of PGD2, U-46619 or PGI2 was demonstrated by the reduction of submaximal contractions to acetylcholine. Our results suggest that prostanoid receptors mediating inhibitory responses of circular muscle predominate in the ileum, whereas in the colon both excitatory and inhibitory prostanoid receptors occur.

References

May 1, 1977·The Journal of Pharmacy and Pharmacology·K G EleyH L Stockley
Feb 1, 1975·Life Sciences·M HambergB Samuelsson
Aug 1, 1971·British Journal of Pharmacology·A Bennett, J Posner
Nov 1, 1968·British Journal of Pharmacology·A BennettG B Scholes
Mar 1, 1980·British Journal of Pharmacology·A BennettG J Sanger
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·E W HORTON, I H MAIN
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·E W HORTON, I H MAIN

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Citations

Jun 1, 1988·Digestive Diseases and Sciences·H W Kao, R D Zipser
Oct 10, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R C de LisleL Meldi
Sep 11, 2002·The Journal of Nutrition·Glen S PattenAnisa Jahangiri
May 1, 1995·Scandinavian Journal of Gastroenterology·Y F LuS Nakayama
May 11, 2021·Cellular and Molecular Gastroenterology and Hepatology·Camille PochardMalvyne Rolli-Derkinderen

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