Regional differences in the risk of triple class failure in European patients starting combination antiretroviral therapy after 1 January 1999

HIV Medicine
A MocroftEuroSIDA Study Group

Abstract

Regional differences across Europe in triple class failure (TCF; the failure of each of the three separate main classes of antiretrovirals (ARVs) with a viral load >1000 HIV-1 RNA copies/mL for >4 months) have not been described. A total of 1956 patients started combination ARV therapy after 1 January 1999, of whom 123 patients developed TCF [6.3%; incidence 16.7 per 1000 person-years of follow-up; 95% confidence interval (CI) 13.7-19.6]. After adjustment, patients from Eastern Europe had a significantly increased incidence of TCF compared with patients from Southern Europe/Argentina (3.05; 95% CI 1.36-6.82; P=0.0067) while patients taking either a boosted protease inhibitor regimen (0.33; 95% CI 0.15-0.74; P=0.0072) or a nonnucleotide reverse transcriptase inhibitor (NNRTI)-based regimen (0.59; 95% CI 0.37-0.94; P=0.026) had a reduced incidence of TCF.

Associated Clinical Trials

References

Jun 28, 2002·The New England Journal of Medicine·Sharon WalmsleyUNKNOWN M98-863 Study Team
Jul 11, 2003·Lancet·A MocroftUNKNOWN EuroSIDA study group
Dec 12, 2003·The New England Journal of Medicine·Gregory K RobbinsUNKNOWN AIDS Clinical Trials Group 384 Team
Mar 8, 2005·BMJ : British Medical Journal·Caroline A SabinUNKNOWN UK Collaborative HIV Cohort (UK CHIC) Study Group
Jun 9, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Wendy P BannisterUNKNOWN EuroSIDA Study Group

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Citations

Mar 10, 2010·Archives of Internal Medicine·Rebecca LodwickAndrew N Phillips
Feb 12, 2010·HIV Medicine·L BansiUNKNOWN UK Collaborative HIV Cohort (CHIC) Study and the Health Protection Agency
May 20, 2015·HIV Medicine·D PodlekarevaUNKNOWN EuroSIDA in EuroCoord
Nov 16, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·UNKNOWN Pursuing Later Treatment Options II (PLATO II) project teamAndrew Phillips

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