Regional differences in treatment response and three year course of schizophrenia across the world

Journal of Psychiatric Research
D NovickEnric Alvarez

Abstract

Data from the Worldwide-Schizophrenia Outpatient Health Outcomes (W-SOHO) study was used to determine the frequency of response and describe the course of disease in outpatients with schizophrenia in different regions of the world. The W-SOHO study was a 3-year, prospective, observational study that included over 17,000 outpatients with schizophrenia from 37 countries classified into six regions (Northern Europe, Southern Europe, Latin America, East Asia, Central & Eastern Europe, North Africa & Middle East). Cox proportional-hazards regression was employed to assess the factors associated with response. Multinomial logistic regression was used to assess the correlates of disease course. We found that approximately two-thirds of the patients (66.4%) achieved response during the 3-year follow up. Response rates varied across regions, and were highest in North Africa & Middle East (84.6%) and Latin America (78.6%) and lowest in Southern Europe (62.1%) and East Asia (60.9%). There were significant differences between the regions in the proportion of patients experiencing continuous remission, remission plus relapse and a persistent symptomatic course, and between the regions in the duration of remission. Overall, Latin America, Ea...Continue Reading

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Citations

May 17, 2018·Archives of Women's Mental Health·Anita Riecher-RösslerJayashri Kulkarni
Feb 7, 2021·Experimental Neurology·Alexandra I KordaStefan Borgwardt
May 25, 2021·Psychiatry Research·Daniel MamahDavid M Ndetei

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