Regional differences in vulnerability of the cerebellar foliations of rats exposed to neonatal X-irradiation

Neuroscience Letters
Hong Peng LiYoshiki Takeuchi

Abstract

The purpose of the present study was to elucidate regional differences in the vulnerability of cerebellar foliations of rats exposed to X-irradiation. Effects of X-irradiation on foliations were examined with respect to histological changes in Purkinje cells and Bergmann glial fibers by calbindin-D28k (CB) and glial fibrillary acidic protein (GFAP) immunohistochemistry, respectively. Wistar rats were exposed to X-irradiation (1.5 Gy) on postnatal day (PND) 1. At 3 weeks of age, the cerebellum was examined. The cerebella of rats exposed to X-irradiation showed smaller and abnormal foliations compared with controls. Fewer cerebellar foliations due to fusion with neighboring folia were observed in folia I-III and VIa-VII. Moreover, the extent of such abnormalities was more severe in the latter folia. CB-immunoreactive (IR) Purkinje cells exhibited thin, short, disoriented dendrites that had invaded the granular layer or white matter. On the other hand, GFAP-IR Bergmann glial fibers had not extended their processes into the molecular layer perpendicular to the pial surface, and they appeared thin and disoriented. Accordingly, the above cerebellar abnormalities were more severe in folia I-III, VIa-VII and X than in other regions. In...Continue Reading

References

May 1, 1990·Neurotoxicology and Teratology·W J SchullR P Jensh
Jan 1, 1989·Brain Research. Developmental Brain Research·S Chen, D E Hillman
Oct 1, 1966·The Journal of Comparative Neurology·M A Haddara, M A Nooreddin
Dec 14, 2002·Brain Research. Developmental Brain Research·Hong Peng LiYoshiki Takeuchi

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Citations

May 12, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ricardo LlorenteMaría-Paz Viveros
Jan 22, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Silvia CerriGraziella Bernocchi

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