Regional Distribution of Fluorine-18-Flubrobenguane and Carbon-11-Hydroxyephedrine for Cardiac PET Imaging of Sympathetic Innervation.

JACC. Cardiovascular Imaging
Jason G E ZeltRob S Beanlands

Abstract

The aim of this study was to investigate the regional distribution of novel 18F-labeled positron emission tomographic (PET) tracer flubrobenguane (FBBG) (whose longer half-life could enable more widespread use) to assess myocardial presynaptic sympathetic nerve function in humans in comparison to [11C]meta-hydroxyephedrine (HED). The sympathetic nervous system (SNS) is vitally linked to cardiovascular regulation and disease. SNS imaging has shown prognostic value. HED is the most commonly used PET tracer for evaluation of sympathetic function in humans, but widespread clinical use is limited because of the short half-life of 11C. A total of 25 participants (n = 6 healthy; n = 14 ischemic cardiomyopathy, left ventricular [LV] ejection fraction [EF] = 34 ± 5%; and n = 5 nonischemic cardiomyopathy, EF = 33 ± 3%) underwent 2 separate PET imaging visits 8.7 ± 7.6 days apart. On 1 visit, participants underwent dynamic HED PET imaging. On a different visit, participants underwent dynamic FBBG PET imaging. The order of testing was random. HED and FBBG global innervation (retention index [RI] and distribution volume [DV]) and regional denervation (% nonuniformity) were quantified to assess regional presynaptic sympathetic innervations. ...Continue Reading

References

Nov 1, 1995·Journal of the American College of Cardiology·D M KayeM D Esler
Mar 15, 1995·Circulation·G WannametheeM Walker
Sep 18, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James T ThackerayJean N Dasilva
Sep 22, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James A Fallavollita, John M Canty
May 11, 2011·Circulation. Cardiovascular Imaging·Ming YuSimon P Robinson
Aug 7, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Ming YuSimon P Robinson
Apr 20, 2013·Current Cardiology Reviews·John E A BlairSanjiv J Shah
May 15, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Takahiro HiguchiStephan G Nekolla
Oct 1, 2013·Journal of the American College of Cardiology·James A FallavollitaJohn M Canty
Jul 6, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Albert J SinusasL Veronica Lee
Jul 18, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rudolf A WernerTakahiro Higuchi
Jul 10, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Vasken DilsizianMark I Travin
Jul 22, 2019·JACC. Cardiovascular Imaging·Jason G E ZeltLisa M Mielniczuk
Dec 10, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Kai Yi WuRobert A deKemp
Apr 30, 2020·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jean Z WangRobert A deKemp
Jun 17, 2020·Seminars in Nuclear Medicine·Gedaliah FarberBenjamin H Rotstein

❮ Previous
Next ❯

Citations

Aug 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jean Z WangRobert A deKemp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.