PMID: 6167971Jan 1, 1981Paper

Regional distribution of gamma- and beta-endorphin-like peptides in the pituitary and brain of the rat

Peptides
D M DorsaM B Chapman

Abstract

Sensitive and specific radioimmunoassays for gamma- and beta-endorphin-like peptides (gamma E and beta E) were used to examine the distribution and relationship of these peptides in the pituitary and in microdissected nuclear brain areas of the male rat. In the pituitary, the highest amounts of gamma E and beta E were found in the neurointermediate region of the gland. On a molar basis, gamma E-like immunoreactivity was found to exist as a relatively constant proportion of beta E-like peptides throughout the pituitary. In the brain, while beta E-like peptides were detected in many brain areas, gamma E-like peptides were detected in only a limited number of sites. In most of these areas, the molar ratio of gamma E to beta E-like peptides closely approximated that found in the pituitary. However, in the ventromedial nucleus of the hypothalamus and nucleus accumbens a higher proportion of gamma E to beta E was measured. These results suggest preferential formation of gamma E or related peptides in certain areas of the brain may occur.

References

Jun 15, 1978·European Journal of Pharmacology·D De WiedH M Greven
Feb 28, 1979·Biochemical and Biophysical Research Communications·J P BurbachD de Wied
Jan 27, 1977·The New England Journal of Medicine·R Guillemin
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R E MainsN Ling
Sep 21, 1978·Nature·S J WatsonJ D Barchas
Sep 1, 1979·Canadian Journal of Biochemistry·M ChrétienN G Seidah
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J RossierR Guillemin
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F BloomR Guillemin
Mar 1, 1979·Archives of General Psychiatry·W M VerhoevenD de Wied
Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·D M DorsaD De Wied
Jul 14, 1978·Biochemical and Biophysical Research Communications·S JegouN Ling
Jul 11, 1977·Biochemical and Biophysical Research Communications·R GuilleminT Vargo
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C H Li, D Chung
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·N LingR Guillemin
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·B Desbuquois, G D Aurbach
Dec 1, 1971·The Journal of Clinical Endocrinology and Metabolism·J VaitukaitisG T Ross
Dec 1, 1964·Endocrinology·H SACHS, Y TAKABATAKE

❮ Previous
Next ❯

Citations

May 1, 1986·Pharmacology, Biochemistry, and Behavior·J C Crabbe, D M Dorsa
Nov 1, 1982·Peptides·G A OlsonD H Coy
May 1, 1982·Peptides·T L O'Donohue, D M Dorsa
May 1, 1982·Peptides·J P Burbach, E R De Kloet
Jan 1, 1986·Neurochemistry International·M Palkovits
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·D D RasmussenC W Wilkinson
Mar 5, 1986·Brain Research·L D KeithJ W Kendall
Dec 31, 1985·Biochemical and Biophysical Research Communications·J L LebouilleJ P Burbach
Jan 1, 1982·Annals of the New York Academy of Sciences·J M van ReeH M van Praag
Jan 14, 1982·Brain Research·J VerhoefD De Wied

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.