PMID: 2505446Jan 1, 1989Paper

Regional distribution of glycoconjugates in normal, transitional and neoplastic human colonic mucosa. A histochemical study using lectins

Virchows Archiv. A, Pathological Anatomy and Histopathology
J CalderóJ M Reñé

Abstract

Regional distribution of glycoconjugates in normal and neoplastic colonic mucosa was studied by means of eight lectins: Dolichos biflorus (DBA), Glycine max (SBA), Triticum vulgare (WGA), Arachis hypogaea (PNA), Griffonia simplicifolia-I (GS-I), Canavalia ensiformis (Con A), Limax flavus (LFA), and Ulex europaeus-I (UEA-I). The lectin binding patterns were examined in 40 normal colonic mucosa (NM) (12 proximal (P) and 28 distal (D], 38 carcinomas (15 P and 23 D), and 31 transitional mucosa (TM) (9 P and 22 D). Sections of NM located 5 cm and 10 cm distant from the tumour and sections from the resection margins (more than 10 cm from the tumour) of the surgical specimens were also studied in 19 cases (6 P and 13 D). In NM, regional differences between the proximal and distal colon were detected with most lectins. DBA, SBA and LFA bound mainly to the goblet cell mucin of the distal colon, while GS-I and UEA-I labelling predominated in proximal colonic mucosa. The lectin reactivity in carcinomas was: DBA 26%, SBA 63%, PNA 95%, GS-I 66%, UEA-I 76%, WGA 100%, Con A 92% and LFA 42%. No regional differences were observed in the lectin patterns of proximal and distal colonic carcinomas nor was any relationship detected between lectin re...Continue Reading

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Citations

Jun 1, 1994·The Histochemical Journal·R F McMahonR W Stoddart
Apr 19, 2007·Journal of Molecular Histology·Giuseppa Esterina LiquoriDomenico Ferri
Nov 1, 1993·Mutation Research·J R Jass
Oct 31, 2009·Journal of Gastroenterology and Hepatology·Jenn Hian Koo, Rupert W L Leong
Jul 1, 1994·Pathology International·J R Jass, A M Roberton
Jul 3, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S A SuttieS Yalamarthi
Jun 10, 2017·International Journal of Molecular Sciences·Guillaume PoirouxPierre Rougé
Sep 7, 2002·International Journal of Cancer. Journal International Du Cancer·Barry Iacopetta
Dec 7, 2007·Physiological Genomics·Lawrence C LaPointeGraeme P Young
Jan 27, 2011·Biochemical Society Transactions·Sylwia ChojnowskaKrzysztof Zwierz

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