PMID: 44543Dec 1, 1979

Regional distribution of membrane-bound gamma-glutamyl transpeptidase activity in mouse brain. Comparison with rabbit brain

Neurochemical Research
V LisýZ Lodin


Activity of membrane-bound gamma-glutamyl transpeptidase (gamma-GTP) was examined in various regions of mouse brain, in capillaries of the cerebral cortex and in telencephalic choroid plexuses. The level of activity in the capillaries was double and that of the choroid plexus nine times that of the gamma-GTP activity found in the brain, septum, hippocampus, hypothalamus, thalamus, cerebellum, frontal cortex, pons, medulla oblongata, and amygdala. Histochemically the gamma-GTP activity was demonstrated in the surface membranes of choroidal cells and in the endothelium of small capillaries. The activities of gamma-GTP of cerebral cortex, choroid plexus, and capillaries from rabbit were 5--17 times greater than those from corresponding areas of mouse brain. While 30 mM methionine stimulated (in vitro) the enzyme from mouse brain, no such effect was observed with the enzyme activity from rabbit brain. The gamma-GTP activity from the capillaries of cerebral cortex of both mouse and rabbit was not affected by the presence of methionine. These findings suggest existence of differences in the specificity of gamma-GTP activity in these two species.


Jun 15, 2011·Cerebral Cortex·Konstantin TziridisPeter Thier
Jul 1, 1984·Neurochemical Research·J Veselý, M Cernoch
Oct 1, 1985·Neurochemical Research·J VeselýM Cernoch
Aug 1, 1989·Journal of Neurochemistry·S A MooreM N Hart


Feb 21, 1977·Journal of Theoretical Biology·S Samuels
Jun 1, 1978·Journal of Neurochemistry·P E Prusiner, S B Prusiner
Jul 9, 1976·Brain Research·B B MrsuljaM Spatz
Apr 1, 1976·Acta Neurologica Scandinavica·F Stastný, Z Rychter
Apr 6, 1973·Science·A Meister
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S S TateA Meister
Jun 1, 1974·Journal of Neurochemistry·P O. OkonkwoJ P Green
Apr 15, 1973·FEBS Letters·M OrlowskiJ P. Green
Jun 1, 1976·Neurochemical Research·E Reyes, E E Prather
Aug 1, 1976·Neurochemical Research·H Sershen, A Lajtha

Related Concepts

Tissue Membrane
Entire Choroid Plexus
Benign Neoplasm of Choroid
Entire Medulla Oblongata
Choroid Plexus of Cerebral Hemisphere
Gamma-glutamyl transferase
Organum Vasculosum Laminae Terminalis

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.