PMID: 698807Oct 6, 1978Paper

Regional distribution of muscarinic cholinergic receptors in rat brain

Brain Research
R M KobayashiH I Yamamura

Abstract

Using the tritiated ligand [3H]quinuclidinyl benzilate ([3H]QNB), a specific muscarinic cholinergic antagonist, the distribution of muscarinic receptors was determined in 75 specific brain regions and nuclei removed by microdissection as well as in large brain areas. [3H]QNB binding was highest in the caudate-putamen; other regions with high binding included the nucleus accumbens, cerebral cortex and hippocampus, certain limbic and thalamic nuclei, superior colliculus, pontine nuclei and the hypoglossal nucleus. Muscarinic cholinergic receptors may be concentrated in these regions. [3H]QNB binding generally correlated well with acetylcholinesterase staining in terminals and is consistent with certain sites as particularly enriched in cholinergic synapses.

References

Jan 1, 1975·Journal of Neurochemistry·M BrownsteinJ M Saavedra
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·H I Yamamura, S H Snyder
Oct 25, 1974·Brain Research·M PalkovitsM Brownstein
Feb 1, 1973·Journal of Neurochemistry·M J KuharG K Aghajanian
Sep 1, 1967·Brain : a Journal of Neurology·C C Shute, P R Lewis

Citations

Nov 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·T DennisB Scatton
Mar 1, 1980·Neurochemical Research·A M Morin, C G Wasterlain
Feb 24, 2007·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicolaas I Bohnen, K A Frey
Sep 8, 1980·Brain Research·S O Kayaalp, N H Neff
Nov 18, 1985·Brain Research·T T SoncrantS I Rapoport
Nov 11, 1983·European Journal of Pharmacology·M G De SimoniJ F Pujol
Dec 9, 1983·European Journal of Pharmacology·L U Naalsund
Dec 1, 1982·Journal of the Neurological Sciences·P Slater, S L Dickinson
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·D A WeldonK J Nicklaus
Jan 1, 1982·Journal of Neuroscience Methods·T C RainbowB S McEwen
Sep 17, 1993·Brain Research. Developmental Brain Research·B L SchlaggarD D O'Leary
May 1, 1993·Neuroscience Research·T Hattori
Jan 1, 1980·Progress in Neurobiology·A Dray
Jan 1, 1986·Progress in Neurobiology·P G Green, I Kitchen
Jan 1, 1986·Progress in Neurobiology·P Kása
Nov 1, 1983·Neuroscience·N Halász, G M Shepherd
Nov 1, 1981·Brain Research Bulletin·I DivacM Nielsen
Apr 1, 1982·Brain Research Bulletin·H KamiyaY Sakurai
Jul 1, 1985·Brain Research Bulletin·D B HooverT E DePorter
Feb 1, 1985·Brain Research Bulletin·N W Pedigo, K R Brizzee
Feb 1, 1989·Brain Research Bulletin·J R PaulyA C Collins
Feb 1, 1990·Brain Research Bulletin·N RavelG Chouvet
Feb 1, 1991·Brain Research Bulletin·G ChambaJ F Pujol
Jan 1, 1986·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A PintorH Michalek
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A RamiJ Clos
Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·P MonmaurM M'Harzi
Mar 1, 1981·Brain Research Bulletin·D B HooverN S Talley
Nov 1, 1983·Clinical and Experimental Pharmacology & Physiology·A K SaxenaK P Bhargava
Jan 1, 1989·Fundamental & Clinical Pharmacology·S LaurentH Schmitt
Nov 1, 1986·Acta Physiologica Scandinavica·J GrenhoffT H Svensson
Mar 1, 1986·Neuropharmacology·K RimvallP G Waser
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K A FreyB W Agranoff
Dec 1, 2010·Behavioural Brain Research·R A Hut, Eddy A Van der Zee
Jul 6, 2010·Journal of Chemical Neuroanatomy·Karolina Rogozinska, Jolanta Skangiel-Kramska
May 28, 2015·Autonomic Neuroscience : Basic & Clinical·Jittima GottsJim Deuchars
Aug 31, 1979·Brain Research·K Yoshida, H Imura
Oct 29, 2011·Brain Research Bulletin·Attila TothLaszlo Detari
Jan 1, 1986·Chronobiology International·M S KafkaN S Tokola
Jun 9, 2016·British Journal of Clinical Pharmacology·Ricardo Alvarez-JimenezJasper Stevens
Mar 21, 2006·Physiology & Behavior·Luis Felipe Souza da Silva, Leda Menescal-de-Oliveira
Apr 1, 1984·Journal of Pharmaceutical Sciences·W C EckelmanR C Reba
Aug 1, 1984·Journal of Neurochemistry·P T OzandM L Oster-Granite
Sep 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Liana Gouveia da SilvaEduardo Colombari
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·A Jean
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M DurandR Quirion
Dec 31, 2019·Pflügers Archiv : European journal of physiology·Werner I FuruyaDébora S A Colombari
Dec 14, 2004·Journal of Biomedical Science·Hong ZhuRobin W Rockhold
Apr 13, 1999·The American Journal of Physiology·M ShiharaA Takeshita

Related Concepts

Brain
Functional Cerebral Localization
Quinuclidines
Cholinergic Receptors
Muscarinic Acetylcholine Receptor

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.