PMID: 1522947Mar 1, 1992Paper

Regional effects of aging on dopaminergic function in the Fischer-344 rat

Neurobiology of Aging
M Friedemann, G A Gerhardt

Abstract

To examine the consequences of aging on nigrostriatal (A9) and mesolimbic (A10) dopamine (DA) function, neurochemical and behavioral measurements were performed in male Fischer-344 rats 6, 12, 18, 24, and 30 months old. Regional analyses of dopaminergic overflow and uptake processes were examined using high-speed (5 Hz) in vivo electrochemical recordings and local drug application techniques. When potassium was used to elicit the presynaptic overflow of dopamine (DA) in striatal areas predominantly innervated by the substantia nigra, the amplitude of DA overflow was significantly lower in 24- and 30-month-old rats (p less than 0.05 and p less than 0.01 vs. 6 months, respectively). Furthermore, in ventral striatum (including the nucleus accumbens) which is innervated primarily by A10 DA cell bodies, potassium-evoked DA overflow release amplitudes were significantly lower in the 18, 24, and 30 month groups (p less than 0.01 vs. 6 months). In addition, age-related differences between the dorsal and ventral striatum were found in a preliminary investigation of DA diffusion and clearance. Local application of nomifensine, a DA uptake inhibitor, significantly increased (p less than 0.05 vs. control) the amplitude of the signal record...Continue Reading

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Citations

Mar 1, 1995·Neurobiology of Aging·R D BurwellM Gallagher
Jul 1, 1995·Neurobiology of Aging·H KametaniJ A Joseph
Aug 1, 1994·Neuroscience Letters·W A Cass, G A Gerhardt
May 1, 1993·Journal of Chemical Neuroanatomy·M ZoliL F Agnati
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Sep 27, 2002·Journal of Neuroscience Methods·Jason J BurmeisterGreg A Gerhardt
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Feb 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Martin LundbladAnders Björklund

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