Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging

Radiology
Hooman HamedaniRahim R Rizi

Abstract

Purpose To assess the feasibility and optimize the accuracy of the multibreath wash-in hyperpolarized helium 3 ((3)He) approach to ventilation measurement by using magnetic resonance (MR) imaging as well as to examine the physiologic differences that this approach reveals among nonsmokers, asymptomatic smokers, and patients with chronic obstructive pulmonary disease (COPD). Materials and Methods All experiments were approved by the local institutional review board and compliant with HIPAA. Informed consent was obtained from all subjects. To measure fractional ventilation, the authors administered a series of identical normoxic hyperpolarized gas breaths to the subject; after each inspiration, an image was acquired during a short breath hold. Signal intensity buildup was fit to a recursive model that regionally solves for fractional ventilation. This measurement was successfully performed in nine subjects: three healthy nonsmokers (one man, two women; mean age, 45 years ± 4), three asymptomatic smokers (three men; mean age, 51 years ± 5), and three patients with COPD (three men; mean age, 59 years ± 5). Repeated measures analysis of variance was performed, followed by post hoc tests with Bonferroni correction, to assess the diff...Continue Reading

References

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Citations

Sep 13, 2016·Academic Radiology·Mu HeYuh-Chin T Huang
Oct 1, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Atsuomi KimuraHideaki Fujiwara
Apr 17, 2018·Physiological Reports·Wendy KangKelly S Burrowes
Apr 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
Sep 25, 2018·Journal of Magnetic Resonance Imaging : JMRI·Marcus J CouchMitchell S Albert
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marcus J CouchGiles Santyr
Jul 13, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix C HornJim M Wild
May 31, 2018·Physiological Reports·Brody H FoyDavid Kay
Dec 8, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Faraz AmzajerdianRahim R Rizi
Jan 29, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Benjamin J PippardPeter E Thelwall
Apr 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderGiles Santyr

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