PMID: 9160231May 1, 1997Paper

Regional gradation of L-type calcium currents in the feline heart with a healed myocardial infarct

Journal of Cardiovascular Electrophysiology
J M PintoR J Myerburg

Abstract

Abnormal action potentials in myocytes adjacent to > 2-month-old feline LV myocardial infarcts (MI) may reflect alterations in Ca2+ currents (Ica). We compared ICa, at 36 degrees C, in subendocardial myocytes isolated from areas adjacent to MI and to ICa in cells from remote areas (> 4 mm away; REM) and control cells from similar regions in normal hearts. Control (CON) myocytes had membrane capacitance of 234 +/- 10 pF (n = 81 cells) compared to 305 +/- 14 pF in REM (71 cells; P < 0.05 from CON) and 237 +/- 11 pF (n = 55 cells) in MI (not different from CON). From Vh = -40 mV; peak ICa elicited by test potentials (-35 to +70 mV) were significantly larger in CON (-1746 +/- 123 pA) and REM (-1795 +/- 142 pA) compared to MI (-1352 +/- 129 pA) (P < 0.05). Peak ICa density was significantly reduced in REM (-6.0 +/- 0.4 pA/pF) or MI (-5.7 +/- 0.4 pA/pF, P < 0.05) compared to CON (-7.5 +/- 0.4 pA/pF). Double exponential ICa decay was similar among groups. Half-inactivation potential (V0.5) was significantly shifted (hyperpolarizing direction) for MI (-29.1 +/- 2.6 mV) and REM (-24.6 +/- 1.2 mV) myocytes compared to -20.3 +/- 1.0 mV in CON. MI slope factor (k; 9.0 +/- 0.5) was significantly different from CON (6.8 +/- 0.3) and REM (7.3...Continue Reading

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Citations

Dec 17, 2008·Cardiovascular Research·Thomas J HundPeter J Mohler
Jun 22, 1999·Journal of Cardiovascular Electrophysiology·F YuanR J Myerburg
Jun 22, 1999·Journal of Cardiovascular Electrophysiology·E Carmeliet
Jan 29, 2002·Journal of Molecular and Cellular Cardiology·Young-Kwon KimStephen F Vatner
Aug 6, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Tetsuo SasanoJ Kevin Donahue
Aug 12, 2006·Journal of Molecular and Cellular Cardiology·Geoffrey S PittPenelope A Boyden
Aug 17, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Sanjeev WassonMary L Dohrmann
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Apr 25, 2018·Frontiers in Physiology·Caroline Mendonca CostaMartin J Bishop

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