Regional grey matter volumetric changes in forensic schizophrenia patients: an MRI study comparing the brain structure of patients who have seriously and violently offended with that of patients who have not.

BMC Psychiatry
B K PuriGraeme M Bydder

Abstract

The aim was to carry out the first voxel-based morphometry study of grey matter changes in the whole brain in schizophrenia associated with a history of seriously and violently offending. Structural cerebral magnetic resonance imaging scans of 26 patients with schizophrenia were analyzed using voxel-based morphometry: 13 of the patients had seriously and violently offended directly as a result of schizophrenia prior to admission, the offences consisting of homicide, attempted murder or wounding with intent to cause grievous bodily harm; the other 13 patients did not have a history of violence. There was no history of comorbid psychoactive substance misuse disorder in any of the patients. Voxelwise generalized linear modelling was applied to the processed magnetic resonance data using permutation-based non-parametric testing, forming clusters at t > 2.3 and testing clusters for significance at p < 0.05, corrected for multiple comparisons across space. The two groups of patients were matched with respect to age, gender and duration of illness, but the group with a history of serious violence was on average receiving a higher dose of antipsychotic medication than the group without a history of violence. There were local regions of...Continue Reading

References

Jan 1, 1986·The American Journal of Psychiatry·S C YudofskyD Williams
Jun 1, 1997·Computers and Biomedical Research, an International Journal·S Bosan, T R Harris
Mar 12, 1998·Brain Research. Brain Research Reviews·F Aboitiz, R García V
Oct 26, 1999·IEEE Transactions on Medical Imaging·D RueckertD J Hawkes
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Sep 24, 2005·Annals of Neurology·John E DesmondPerry B Shieh
Dec 31, 2005·Schizophrenia Bulletin·Kris Naudts, Sheilagh Hodgins
Feb 10, 2006·Behavioural Brain Research·Ian BarkatakiTonmoy Sharma
Aug 31, 2007·The American Journal of Psychiatry·Veena M NarayanTonmoy Sharma
Oct 12, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Zhiye Chen, Lin Ma

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Citations

Aug 24, 2011·Schizophrenia Bulletin·Michael Soyka
May 9, 2008·BMC Psychiatry·Basant K Puri
Mar 17, 2010·Psychiatry Research·Yaling YangKatherine L Narr
Nov 12, 2016·The Psychiatric Clinics of North America·Delaney SmithDouglas Misquitta
Aug 15, 2017·CNS Spectrums·Bernhard BogertsStephanie Breitschuh
Nov 2, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·WonKyung ChoSang-Hyuk Lee
Jul 7, 2019·Brain Imaging and Behavior·Ashly Sajous-TurnerKent A Kiehl
Jan 22, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Stéphane Richard-DevantoyFabrice Jollant
Mar 18, 2020·Frontiers in Psychiatry·Andràs TikàszAlexandre Dumais
Sep 20, 2019·PeerJ·Ying-Dong ZhangXiao-Ping Wang

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