Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotonin

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Zachary A RoddWilliam J McBride

Abstract

The meso-limbic dopamine (DA) system has an important role in regulating alcohol drinking. Previous findings from our laboratory indicated that Wistar rats self-administered ethanol (EtOH) directly into the posterior, but not anterior, ventral tegmental area (VTA), and that coadministration of a DA D(2,3) receptor agonist or a serotonin-3 (5-HT3) receptor antagonist blocked EtOH self-administration. In addition, we reported that alcohol-preferring (P) rats self-administered acetaldehyde (ACD), the first metabolite of EtOH, into the posterior VTA. The objectives of this study were to compare the reinforcing effects of EtOH and ACD within the VTA of P rats to examine the possibility that the reinforcing effects of EtOH within the VTA may be mediated by its conversion to ACD. Adult female P rats were stereotaxically implanted with guide cannulae aimed at either the posterior or anterior VTA. At 1 week after surgery, rats were placed in standard two-lever (active and inactive) experimental chambers for a total of seven to eight sessions. The 4-h sessions were conducted every other day. The results indicated that (a) 75-300 mg% (17-66 mM) EtOH and 6-90 microM ACD were self-administered into the posterior, but not anterior, VTA; (b) ...Continue Reading

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Citations

May 15, 2013·Neuropharmacology·Satoshi Ikemoto, Antonello Bonci
Feb 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rubing Zhao-SheaAndrew R Tapper
Sep 12, 2006·Addiction Biology·Richard L BellWilliam J McBride
Sep 18, 2012·Addiction Biology·Hamid R NooriAnita C Hansson
Dec 15, 2010·The Journal of Pharmacology and Experimental Therapeutics·Sheketha R HauserZachary A Rodd
Jan 3, 2012·The Journal of Pharmacology and Experimental Therapeutics·Yanzhong GuanJiang-Hong Ye
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Satoshi IkemotoZhong-Hua Liu
Sep 17, 2013·Neurotoxicology and Teratology·Michelle L TomaszyckiScott E Bowen
Mar 19, 2014·Pharmacology, Biochemistry, and Behavior·Christian BrabantEtienne Quertemont
Mar 16, 2011·Neuroscience and Biobehavioral Reviews·Dave J Hayes, Andrew J Greenshaw
Mar 25, 2008·Alcohol·Garth E Resch, C Wayne Simpson
Nov 6, 2007·Alcohol·Michael E NizhnikovNorman E Spear
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Etienne QuertemontRoberta J Ward
Jun 3, 2009·Alcoholism, Clinical and Experimental Research·Zheng-Ming DingWilliam J McBride
Nov 23, 2006·Alcoholism, Clinical and Experimental Research·Michael E NizhnikovNorman E Spear
Jun 2, 2006·Alcoholism, Clinical and Experimental Research·Sandra L Morzorati, Rita L Marunde
Feb 24, 2009·The Journal of Comparative Neurology·Jennifer KauflingMichel Barrot
Feb 22, 2011·Alcoholism, Clinical and Experimental Research·Eduardo KarahanianYedy Israel
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