Regional Homogeneity Abnormalities in Early-Onset and Adolescent-Onset Conduct Disorder in Boys: A Resting-State fMRI Study

Frontiers in Human Neuroscience
Wanyi CaoJun Liu

Abstract

Purpose: Developmental taxonomic theory posits that formation of early-onset conduct disorder (EO-CD), is considered to have a neurodevelopmental etiology and have more severe psychosocial and neuropsychological dysfunction than adolescent-onset CD (AO-CD), which is thought to stem largely from social mimicry of deviant peers. The purpose of the current study was to investigate whether regional homogeneity (ReHo), denoting the spontaneous brain activity, supports developmental taxonomic theory in a resting state (rs). Materials and Methods: Rs-functional magnetic resonance imaging (fMRI) examinations were administered to 36 EO-CD patients, 32 AO-CD patients, and 30 healthy controls (HCs). All participants were male adolescents, aged between 12 and 17 years old. A one-way analysis of covariance (ANCOVA), with age and IQ as covariates, was performed to identify regions with significant group differences in ReHo values, followed by a post hoc analyses. Results: Compared with the AO-CD groups, EO-CD had higher ReHo values in the right middle/inferior frontal gyrus. Compared with the HCs, the EO-CD group exhibited lower ReHo values in the left precuneus, left middle occipital gyrus, left cerebellum posterior lobe and the right infer...Continue Reading

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Citations

Apr 25, 2021·Neuropsychologia·Fengmei LuJiansong Zhou
Dec 14, 2021·Frontiers in Neuroinformatics·Sreevalsan S Menon, K Krishnamurthy

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Software Mentioned

Statistical Package for Social Sciences
rs
fMRI Data Analysis Toolkit
fMRI
Data Processing Assistant for Resting State fMRI

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