Regional homogeneity changes in patients with neuromyelitis optica revealed by resting-state functional MRI

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Peipeng LiangKuncheng Li

Abstract

Resting-state brain activity in neuromyelitis optica (NMO) patients can give clues to the pathophysiology of the disorder, and may be helpful in diagnosis; however, it has been less explored using functional MRI (fMRI). In the current study, we used a regional homogeneity (ReHo) method to investigate NMO-related modulations of neural activity in the resting state. Resting-state fMRIs acquired in 17 NMO patients as well as in 17 age- and sex-matched normal controls were compared. Kendall's coefficient of concordance was used to measure the regional homogeneity. Correlative analyses were performed to explore the relationship between the expanded disability status scale (EDSS), disease duration and ReHo in regions with significant group differences. Comparing the NMO group with the healthy controls, we found ReHo decreased in extensive brain regions, including the left anterior cingulate, left medial frontal gyrus, left posterior cingulate, right precuneus and right middle temporal gyrus; and increased in the right inferior frontal gyrus. These results demonstrate that neural activity in the resting state is changed in patients with NMO. The present study reveals clear abnormalities of NMO patients in the baseline activities that ...Continue Reading

References

Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jul 29, 1998·Brain : a Journal of Neurology·N SadatoM Hallett
Mar 17, 1999·NeuroImage·C GoutteL K Hansen
Dec 28, 1999·Magnetic Resonance Imaging·R BaumgartnerW Richter
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R Aron, Russell A Poldrack
Jul 13, 2006·Archives of Neurology·Sean J PittockVanda A Lennon
May 30, 2007·Brain : a Journal of Neurology·Yong LiuTianzi Jiang
Aug 21, 2007·Lancet Neurology·Dean M WingerchukBrian G Weinshenker
Jan 16, 2008·Archives of Neurology·Frédéric BlancJérôme de Seze

❮ Previous
Next ❯

Citations

Sep 18, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-B ChansonJ de Seze
Sep 26, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jian GuoLi He
Apr 17, 2015·Multiple Sclerosis and Related Disorders·Lucy A Matthews, Jacqueline A Palace
Mar 24, 2016·Journal of X-ray Science and Technology·Zhen TanGuoming Luan
Sep 5, 2015·AJNR. American Journal of Neuroradiology·Q WangC Yu
Dec 29, 2013·NeuroImage. Clinical·Anne-Marie DogonowskiHartwig Roman Siebner
Aug 28, 2014·NeuroImage. Clinical·Lalit GuptaWalter H Backes
Jul 26, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Yaou LiuJinhui Wang
Oct 14, 2018·Human Brain Mapping·Xi GuoChunshui Yu
May 14, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Filippo SavoldiMassimo Filippi
May 18, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Maria Assunta RoccaMassimo Filippi
Apr 6, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xin HuangUNKNOWN Oculopathy fMRI study group
Jun 29, 2021·Frontiers in Neuroscience·Dongpeng WuJinping Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Transposon de-silencing

Transposon silencing is a form of transcriptional gene silencing. These gene silencing mechanisms are impaired in Amyotrophic lateral sclerosis (ALS). Here are the latest discoveries pertaining to transposon silencing and this disease.