Regional homogeneity changes in patients with primary insomnia

European Radiology
Tianyue WangJun-Zhang Tian

Abstract

The study aimed to explore the regional spontaneous activity changes in primary insomnia (PI) patients. Based on the resting-state fMRI datasets acquired from 59 PI patients and 47 healthy controls, a two-sample t-test was performed on individual normalized regional homogeneity (ReHo) maps. Relationships between abnormal ReHo values and the Pittsburgh Sleep Quality Index (PSQI), the self-rating anxiety scale (SAS) and the self-rating depression scale (SDS) were investigated with Pearson correlation analysis. In PI patients, we found increased ReHo in the left insula, right anterior cingulate gyrus, bilateral precentral gyrus and left cuneus, as well as decreased ReHo in the right middle cingulate cortex and left fusiform (p < 0.05, AlphaSim-corrected). We also found a significant positive correlation between increased ReHo in the left insula and SAS scores, decreased ReHo in the right middle cingulated cortex and SDS, SAS scores as well as a negative correlation between increased ReHo in the right precentral gyrus and SDS scores (p < 0.05). Our study found abnormal spontaneous activities in multiple brain regions, especially in emotion-related areas in PI patients. Alterative activities in these regions might contribute to an u...Continue Reading

References

Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Dec 31, 2002·The American Journal of Psychiatry·Richard J DavidsonNed H Kalin
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Oct 30, 2004·The American Journal of Psychiatry·Eric A NofzingerDavid J Kupfer
Dec 17, 2004·Behavioral Sleep Medicine·Daniel J TaylorH Heith Durrence
Nov 2, 2005·The Journal of Clinical Psychiatry·Norifumi TsunoKaren Ritchie
May 6, 2006·The International Journal of Neuropsychopharmacology·Yodphat KrauszOmer Bonne
Jun 20, 2006·Biological Psychiatry·Martin P Paulus, Murray B Stein
Mar 1, 2008·Journal of Psychopharmacology·Morgan HaldaneSophia Frangou
Jul 24, 2008·Human Brain Mapping·Tao WuPiu Chan
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Georgina CanoClifford B Saper
May 29, 2009·The European Journal of Neuroscience·D RiemannM Berger
Jun 2, 2009·Sleep Medicine Reviews·Dieter RiemannChristoph Nissen
Feb 9, 2010·Sleep Medicine Reviews·Chiara BaglioniDieter Riemann
Feb 19, 2011·Nature Reviews. Neuroscience·Alexander J ShackmanRichard J Davidson
Apr 5, 2011·European Journal of Radiology·Zhaoyang HuangKuncheng Li
Sep 11, 2012·Biological Psychology·Kai SpiegelhalderChristoph Nissen
Oct 13, 2012·Frontiers in Neurology·Diederick StoffersEus J W Van Someren
Dec 5, 2012·Neuroscience and Biobehavioral Reviews·Nynke A GroenewoldSergi G Costafreda
Feb 14, 2013·Behavioral Sleep Medicine·Janet M Y CheungBandana Saini
Nov 2, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·J MaesR Cluydts
Jan 15, 2014·Biological Psychology·Michael C ChenIan H Gotlib
Jan 23, 2015·PloS One·Joy PerrierMarie-Laure Bocca

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Citations

Feb 8, 2018·Brain Imaging and Behavior·Meng LiGuihua Jiang
Mar 3, 2018·AJNR. American Journal of Neuroradiology·R PangK Li
Aug 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea N Goldstein-PiekarskiLeanne M Williams
Feb 12, 2020·Brain Imaging and Behavior·Yifei ZhuMing Zhang
Mar 9, 2018·Frontiers in Psychiatry·Xiaofen MaTianyue Wang
Sep 14, 2019·Journal of Sleep Research·Kira V JespersenPeter Vuust
Dec 23, 2019·Sleep & Breathing = Schlaf & Atmung·Binghu JiangZhanhui Gao
May 6, 2020·Brain Imaging and Behavior·Xi-Jian DaiYongjun Wang
May 5, 2017·Frontiers in Neuroscience·Feng-Mei LuZhen Yuan
Mar 3, 2021·Brain Imaging and Behavior·Longmao ChenDahua Yu
Sep 10, 2021·Brain Imaging and Behavior·Yan ShaoHongqiang Sun
Dec 1, 2021·Brain Imaging and Behavior·Youling BaiHuazhan Yin

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