Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study

PloS One
Chun-Hong LiuChuan-Yue Wang


We sought to use a regional homogeneity (ReHo) approach as an index in resting-state functional magnetic resonance imaging (fMRI) to investigate the features of spontaneous brain activity within the default mode network (DMN) in patients suffering from bipolar depression (BD). Twenty-six patients with BD and 26 gender-, age-, and education-matched healthy subjects participated in the resting-state fMRI scans. We compared the differences in ReHo between the two groups within the DMN and investigated the relationships between sex, age, years of education, disease duration, the Hamilton Rating Scale for Depression (HAMD) total score, and ReHo in regions with significant group differences. Our results revealed that bipolar depressed patients had increased ReHo in the left medial frontal gyrus and left inferior parietal lobe compared to healthy controls. No correlations were found between regional ReHo values and sex, age, and clinical features within the BD group. Our findings indicate that abnormal brain activity is mainly distributed within prefrontal-limbic circuits, which are believed to be involved in the pathophysiological mechanisms underlying bipolar depression.


Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·E KoechlinJ Grafman
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Jun 5, 2002·Archives of General Psychiatry·Lewis L JuddMartin B Keller
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Aug 2, 2003·The International Journal of Neuropsychopharmacology·Lewis L JuddMartin Keller
Mar 12, 2004·Biological Psychiatry·In Kyoon LyooPerry F Renshaw
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Apr 28, 2004·NeuroImage·Yufeng ZangLixia Tian
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Sep 2, 2005·Nature Reviews. Neuroscience·Morten L Kringelbach
Oct 18, 2005·Bipolar Disorders·Gin S MalhiRon Shnier
Mar 1, 2008·Journal of Psychopharmacology·Morgan HaldaneSophia Frangou
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Jul 24, 2008·Human Brain Mapping·Tao WuPiu Chan
May 8, 2009·Journal of Affective Disorders·Heike TostMarcella Rietschel
Jul 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Amanda K Y MakTatia M C Lee
Sep 29, 2009·NeuroImage·Xi-Nian ZuoMichael P Milham
Mar 2, 2010·Neuron·Jessica R Andrews-HannaRandy L Buckner
Mar 23, 2010·Biological Psychiatry·Emre BoraChristos Pantelis
Mar 24, 2010·Radiology·Nivedita AgarwalPerry F Renshaw
Apr 13, 2010·Neuroscience Letters·Dinesh K ShuklaRalph Axel Müller
May 4, 2010·Journal of Mental Health·Lena Palaniyappan, David Andrew Cousins
Jun 18, 2010·Psychiatry Research·Dost OngürPerry F Renshaw
Feb 16, 2011·Bipolar Disorders·Chi-Hua ChenEd T Bullmore

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